Transmissibility, infectivity and immunogenicity of a live human parainfluenza type 3 virus vaccine (HPIV3cp45) among susceptible infants and toddlers

Shabir A. Madhi, Clare Cutland, Yuwei Zhu, Jill G. Hackell, Frances Newman, Nigel Blackburn, Brian R. Murphy, Robert B. Belshe, Ruth A. Karron, Anne M. Deatly, William C. Gruber, David I. Bernstein, Peter F. Wright

Research output: Contribution to journalArticlepeer-review

Abstract

Background: This study examined the transmissibility between young children of an intranasally administered live attenuated human parainfluenza virus type 3 (HPIV3)-cp45 vaccine candidate. Methods: Eighty subjects were enrolled in playgroups among whom there was at least one infected vaccinee in close contact with a seronegative placebo recipient over 21 days without a confounding infection with wtHPIV3. Following vaccination viral cultures were obtained on nine occasions to detect shedding and transmission of HPIV3cp45. Serum antibody titers were measured before and 7 weeks after vaccination. Results: No child fulfilled the criteria for transmission of HPIV3cp45 giving a risk of transmission of 0.04 (95% CI 0.01-0.19), hence establishing that HPIV3cp45 is less infectious than wtHPIV3 and risk of transmission is not a limitation to further clinical development of this vaccine candidate.

Original languageEnglish (US)
Pages (from-to)2432-2439
Number of pages8
JournalVaccine
Volume24
Issue number13
DOIs
StatePublished - Mar 20 2006

Keywords

  • Immunogenicity
  • Live-attenuated
  • Parainfluenza virus type 3
  • Safety
  • Transmissibility
  • Vaccine

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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