Translocator protein (TSPO) and stress cascades in mouse models of psychosis with inflammatory disturbances

Daisuke Fukudome, Lindsay N. Hayes, Travis E. Faust, Catherine A. Foss, Mari A. Kondo, Brian J. Lee, Atsushi Saito, Shin ichi Kano, Jennifer M. Coughlin, Atsushi Kamiya, Martin G. Pomper, Akira Sawa, Minae Niwa

Research output: Contribution to journalArticle

Abstract

Changes in inflammatory cascades have been implicated in the underlying pathophysiology of psychosis. Translocator protein 18 kDa (TSPO) has been used to assess neuroinflammatory processes in psychotic disorders. Nonetheless, it is unclear whether TSPO, a mitochondrial protein, can be interpreted as a general marker for inflammation in diseases involving psychosis. To address this question, we investigated TSPO signaling in representative mouse models for psychosis with inflammatory disturbances. The maternal immune activation and cuprizone short-term exposure models show different TSPO signaling. Furthermore, we observed similarities and differences in their respective stress pathways including stress hormone signaling and oxidative stress that are functionally interconnected with the inflammatory responses. We propose that more careful studies of TSPO distribution in neuroinflammation and other stress cascades associated with psychotic symptoms will allow us to understand the biological mechanisms underlying psychosis-related behaviors.

Original languageEnglish (US)
Pages (from-to)492-497
Number of pages6
JournalSchizophrenia Research
Volume197
DOIs
StatePublished - Jul 2018

Keywords

  • Cuprizone short-term exposure (CSE)
  • Inflammatory disturbances
  • Maternal immune activation (MIA)
  • Psychosis
  • Stress cascades
  • Translocator protein 18 kDa (TSPO)

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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