TY - JOUR
T1 - Translocation carcinomas of the kidney
AU - Argani, Pedram
AU - Ladanyi, Marc
N1 - Funding Information:
This work was supported in part by NIH RO1 CA95785 (to ML).
PY - 2005/6
Y1 - 2005/6
N2 - A significant proportion of RCCs of children and young adults bear specific chromosome translocations that result in gene fusions that involve members of the MiTF/TFE transcription factor family. These include the Xp11-translocation carcinomas, which bear TFE3 gene fusions, and the renal carcinomas with the t(6;11)(p21;q12), which bear an Alpha-TFEB gene fusion. Both types of translocation result in overexpression of the fusion gene products, such that nuclear labeling for TFE3 or TFEB by immunohistochemistry is a sensitive and specific marker of these respective tumor types. The clinical behavior of these neoplasms relative to conventional, adult-type renal carcinomas remains to be determined, and will be an important area of future investigation.
AB - A significant proportion of RCCs of children and young adults bear specific chromosome translocations that result in gene fusions that involve members of the MiTF/TFE transcription factor family. These include the Xp11-translocation carcinomas, which bear TFE3 gene fusions, and the renal carcinomas with the t(6;11)(p21;q12), which bear an Alpha-TFEB gene fusion. Both types of translocation result in overexpression of the fusion gene products, such that nuclear labeling for TFE3 or TFEB by immunohistochemistry is a sensitive and specific marker of these respective tumor types. The clinical behavior of these neoplasms relative to conventional, adult-type renal carcinomas remains to be determined, and will be an important area of future investigation.
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U2 - 10.1016/j.cll.2005.01.008
DO - 10.1016/j.cll.2005.01.008
M3 - Review article
C2 - 15848741
AN - SCOPUS:17444381939
SN - 0272-2712
VL - 25
SP - 363
EP - 378
JO - Clinics in laboratory medicine
JF - Clinics in laboratory medicine
IS - 2
ER -