Translocation (8;21) acute myeloid leukemia presenting as severe aplastic anemia

Enkhtsetseg Purev, Bogdan Dumitriu, Christopher Hourigan, Neal S. Young, Danielle M. Townsley

Research output: Contribution to journalArticle

Abstract

We report a case of t(8;21) acute myeloid leukemia presenting as severe aplastic anemia. While initial bone marrow biopsy lacked any cytogenetic abnormalities in 20 analyzed metaphases, repeat bone marrow biopsy eight days later demonstrated this translocation. Initial cytogenetic analysis of 20 metaphases was therefore insufficient to make the diagnosis of hypocellular acute myeloid leukemia. We discuss that further complementary molecular tests, such as CGH, would likely provide a more robust diagnosis of hematopoietic diseases.

Original languageEnglish (US)
Pages (from-to)46-48
Number of pages3
JournalLeukemia Research Reports
Volume3
Issue number2
DOIs
StatePublished - Jan 1 2015
Externally publishedYes

Fingerprint

Aplastic Anemia
Metaphase
Acute Myeloid Leukemia
Bone Marrow
Biopsy
Cytogenetic Analysis
Chromosome Aberrations

Keywords

  • Acute leukemia
  • Aplastic anemia
  • Comparative genomic hybridization
  • T(8;21)

ASJC Scopus subject areas

  • Hematology
  • Oncology

Cite this

Translocation (8;21) acute myeloid leukemia presenting as severe aplastic anemia. / Purev, Enkhtsetseg; Dumitriu, Bogdan; Hourigan, Christopher; Young, Neal S.; Townsley, Danielle M.

In: Leukemia Research Reports, Vol. 3, No. 2, 01.01.2015, p. 46-48.

Research output: Contribution to journalArticle

Purev, Enkhtsetseg ; Dumitriu, Bogdan ; Hourigan, Christopher ; Young, Neal S. ; Townsley, Danielle M. / Translocation (8;21) acute myeloid leukemia presenting as severe aplastic anemia. In: Leukemia Research Reports. 2015 ; Vol. 3, No. 2. pp. 46-48.
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