Translational strategies for cancer prevention in liver

Thomas W. Kensler; Geng Sun Qian; Jian Guo Chen; John D. Groopman

doi:10.1038/nrc1076

Translational strategies for cancer prevention in liver

Thomas W. Kensler, Geng Sun Qian, Jian Guo Chen, John D. Groopman

Bloomberg School of Public Health

Research output: Contribution to journal › Review article › peer-review

173 Scopus citations

Abstract

Unlike many other types of human cancer, the aetiology of liver cancer is well understood. Infection with hepatitis viruses, coupled with dietary exposure to the fungal toxin aflatoxin, increases the risk of the disease. Although primary prevention, based on vaccination and avoiding exposure to these agents, is an appealing option, such strategies will require considerable investment of time and resources to be successful. In the developing world - where the burden of liver cancer is highest - immediate, practical and economical approaches are essential. So, targeted chemoprevention might be most appropriate for the present generation of individuals at risk.

Original language	English (US)
Pages (from-to)	321-329
Number of pages	9
Journal	Nature Reviews Cancer
Volume	3
Issue number	5
DOIs	https://doi.org/10.1038/nrc1076
State	Published - May 2003

ASJC Scopus subject areas

Oncology
Cancer Research

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title = "Translational strategies for cancer prevention in liver",

abstract = "Unlike many other types of human cancer, the aetiology of liver cancer is well understood. Infection with hepatitis viruses, coupled with dietary exposure to the fungal toxin aflatoxin, increases the risk of the disease. Although primary prevention, based on vaccination and avoiding exposure to these agents, is an appealing option, such strategies will require considerable investment of time and resources to be successful. In the developing world - where the burden of liver cancer is highest - immediate, practical and economical approaches are essential. So, targeted chemoprevention might be most appropriate for the present generation of individuals at risk.",

author = "Kensler, {Thomas W.} and Qian, {Geng Sun} and Chen, {Jian Guo} and Groopman, {John D.}",

note = "Funding Information: Our work is supported in part by United States Public Health Services grants from the National Cancer Institute and the National Institute of Environmental Health Sciences, as well as by the Science & Technology Commission of Shanghai Municipality, Shanghai Municipal Health Bureau and Jiangsu Province Department of Health.",

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AU - Kensler, Thomas W.

AU - Qian, Geng Sun

AU - Chen, Jian Guo

AU - Groopman, John D.

N1 - Funding Information: Our work is supported in part by United States Public Health Services grants from the National Cancer Institute and the National Institute of Environmental Health Sciences, as well as by the Science & Technology Commission of Shanghai Municipality, Shanghai Municipal Health Bureau and Jiangsu Province Department of Health.

PY - 2003/5

Y1 - 2003/5

N2 - Unlike many other types of human cancer, the aetiology of liver cancer is well understood. Infection with hepatitis viruses, coupled with dietary exposure to the fungal toxin aflatoxin, increases the risk of the disease. Although primary prevention, based on vaccination and avoiding exposure to these agents, is an appealing option, such strategies will require considerable investment of time and resources to be successful. In the developing world - where the burden of liver cancer is highest - immediate, practical and economical approaches are essential. So, targeted chemoprevention might be most appropriate for the present generation of individuals at risk.

AB - Unlike many other types of human cancer, the aetiology of liver cancer is well understood. Infection with hepatitis viruses, coupled with dietary exposure to the fungal toxin aflatoxin, increases the risk of the disease. Although primary prevention, based on vaccination and avoiding exposure to these agents, is an appealing option, such strategies will require considerable investment of time and resources to be successful. In the developing world - where the burden of liver cancer is highest - immediate, practical and economical approaches are essential. So, targeted chemoprevention might be most appropriate for the present generation of individuals at risk.

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Translational strategies for cancer prevention in liver

Abstract

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