Abstract
The goal of this component of the meeting was to discuss novel therapeutics that attenuate inflammatory pathways, enhance drug delivery into the brain and/or bypass the blood-brain barrier (BBB). Presentations included discussions of (i) antiretroviral drugs packaged into nanoparticles by Howard Gendelman, (ii) how to engage the nasal epithelium and its closely associated neural fibers as a route for drug entry to the brain, by William H. Frey and Lynn Pulliam, and (iii) antioxidant gene delivery to neurons using vector systems that can protect neurons against HIV-associated toxicity, by David Strayer. The session was capped by active discourse among leaders in the field of adjunctive therapies in a broad range of scientific disciplines.
Original language | English (US) |
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Pages (from-to) | 14-19 |
Number of pages | 6 |
Journal | Journal of Neuroimmune Pharmacology |
Volume | 2 |
Issue number | 1 |
DOIs | |
State | Published - Mar 2007 |
Keywords
- Anti-inflammatory
- Antioxidants
- Blood-brain barrier
- Gene delivery
- HIV-1 proteins
- Lentiviruses
- Microglia
- Mononuclear phagocytes
- NeuroAIDS therapeutics
ASJC Scopus subject areas
- Neuroscience (miscellaneous)
- Immunology and Allergy
- Immunology
- Pharmacology