Translational research in pediatric contrast-enhanced ultrasound

Anush Sridharan, Misun Hwang, Shelby Kutty, M. Beth McCarville, Harriet J. Paltiel, Maciej Piskunowicz, Sphoorti Shellikeri, Elizabeth Silvestro, George A. Taylor, Ryne A. Didier

Research output: Contribution to journalReview articlepeer-review


The role of contrast-enhanced ultrasound (CEUS) imaging is being widely explored by various groups for its use in the pediatric population. Clinical implementation of new diagnostic or therapeutic techniques requires extensive and meticulous preclinical testing and evaluation. The impact of CEUS will be determined in part by the extent to which studies are oriented specifically toward a pediatric population. Rather than simply applying principles and techniques used in the adult population, these studies are expected to advance and augment preexisting knowledge with pediatric-specific information. To further develop this imaging modality for use in children, pediatric-focused preclinical research is essential. In this paper we describe the development and implementation of the pediatric-specific preclinical animal and phantom models that are being used to evaluate CEUS with the goal of clinical translation to children.

Original languageEnglish (US)
Pages (from-to)2425-2436
Number of pages12
JournalPediatric radiology
Issue number12
StatePublished - Nov 2021


  • Children
  • Contrast-enhanced ultrasound
  • Fetus
  • Neonates
  • Phantom
  • Translational research
  • Ultrasound
  • Ultrasound contrast agents

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Radiology Nuclear Medicine and imaging


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