Translational Research in Melanoma

Susan Tsai; Michael S. Sabel

doi:10.1016/j.soc.2007.12.003

Translational Research in Melanoma

Susan Tsai, Michael S. Sabel

Research output: Contribution to journal › Review article › peer-review

3 Scopus citations

Abstract

Current treatment of malignant melanoma exemplifies not only the need for translational research but also many of the challenges of moving from bench to bedside. Melanoma remains unique among solid tumors in that its treatment primarily is surgical. Radiation is of limited benefit, and chemotherapy has been disappointing in both the adjuvant and metastatic settings. This leaves clinicians with few options for reducing the chance of recurrence after surgery and for treating unresectable disease. With this in mind, there has been a fervent attempt to identify novel approaches to melanoma therapy and translate them into clinical use.

Original language	English (US)
Pages (from-to)	391-419
Number of pages	29
Journal	Surgical Oncology Clinics of North America
Volume	17
Issue number	2
DOIs	https://doi.org/10.1016/j.soc.2007.12.003
State	Published - Apr 2008
Externally published	Yes

ASJC Scopus subject areas

Surgery
Oncology

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10.1016/j.soc.2007.12.003

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title = "Translational Research in Melanoma",

abstract = "Current treatment of malignant melanoma exemplifies not only the need for translational research but also many of the challenges of moving from bench to bedside. Melanoma remains unique among solid tumors in that its treatment primarily is surgical. Radiation is of limited benefit, and chemotherapy has been disappointing in both the adjuvant and metastatic settings. This leaves clinicians with few options for reducing the chance of recurrence after surgery and for treating unresectable disease. With this in mind, there has been a fervent attempt to identify novel approaches to melanoma therapy and translate them into clinical use.",

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AU - Sabel, Michael S.

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N2 - Current treatment of malignant melanoma exemplifies not only the need for translational research but also many of the challenges of moving from bench to bedside. Melanoma remains unique among solid tumors in that its treatment primarily is surgical. Radiation is of limited benefit, and chemotherapy has been disappointing in both the adjuvant and metastatic settings. This leaves clinicians with few options for reducing the chance of recurrence after surgery and for treating unresectable disease. With this in mind, there has been a fervent attempt to identify novel approaches to melanoma therapy and translate them into clinical use.

AB - Current treatment of malignant melanoma exemplifies not only the need for translational research but also many of the challenges of moving from bench to bedside. Melanoma remains unique among solid tumors in that its treatment primarily is surgical. Radiation is of limited benefit, and chemotherapy has been disappointing in both the adjuvant and metastatic settings. This leaves clinicians with few options for reducing the chance of recurrence after surgery and for treating unresectable disease. With this in mind, there has been a fervent attempt to identify novel approaches to melanoma therapy and translate them into clinical use.

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Translational Research in Melanoma

Abstract

ASJC Scopus subject areas

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