Translational relevance of mouse models of atopic dermatitis

Justin Choi, Nishadh Sutaria, Youkyung Sophie Roh, Zachary Bordeaux, Martin P. Alphonse, Shawn G. Kwatra, Madan M. Kwatra

Research output: Contribution to journalReview articlepeer-review


The complexity of atopic dermatitis (AD) continues to present a challenge in the appropriate selection of a mouse model because no single murine model completely recapitulates all aspects of human AD. This has been further complicated by recent evidence of the distinct AD endotypes that are dictated by unique patterns of inflammation involving Th1, Th2, Th17, and Th22 axes. A review of currently used mouse models demonstrates that while all AD mouse models consistently exhibit Th2 inflammation, only some demonstrate concomitant Th17 and/or Th22 induction. As the current understanding of the pathogenic contributions of these unique endotypes and their potential therapeutic roles expands, ongoing efforts to maximize a given mouse model’s homology with human AD necessitates a close evaluation of its distinct immunological signature.

Original languageEnglish (US)
Article number613
Pages (from-to)1-11
Number of pages11
JournalJournal of Clinical Medicine
Issue number4
StatePublished - 2021


  • Atopic dermatitis
  • Dermatology
  • Eczema
  • Immunology
  • Mouse models

ASJC Scopus subject areas

  • Medicine(all)


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