Abstract
For years, strategies have been proposed to improve translational success in stroke research by improving the quality of animal studies. However, articles that report preclinical intracerebral hemorrhage (ICH) studies continue to lack adequate qualitative and quantitative descriptions of fresh brain tissue collection. They also tend to lack transparency about animal model quality. We conducted a systematic review of 82 ICH research articles to determine the level of detail reported for brain tissue collection. We found that only 24 (29 %) reported the volume, weight, or thickness of tissue collected and a specific description of the anatomical location. Thus, up to 71 % of preclinical ICH research articles did not properly define how fresh specimens were collected for biochemical measurements. Such omissions may impede reproducibility of results between laboratories. Although existing criteria have improved the quality of preclinical stroke studies, ICH researchers need to identify specific guidelines and strategies to avoid pitfalls, minimize bias, and increase reproducibility in this field.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 384-389 |
| Number of pages | 6 |
| Journal | Translational Stroke Research |
| Volume | 6 |
| Issue number | 5 |
| DOIs | |
| State | Published - Apr 25 2015 |
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Keywords
- Basic science
- Hematoma
- Intracerebral hemorrhage
- Multidisciplinary collaboration
- Preclinical criteria
- Translational stroke research
ASJC Scopus subject areas
- Clinical Neurology
- Neuroscience(all)
- Cardiology and Cardiovascular Medicine
Cite this
Translational Intracerebral Hemorrhage : a Need for Transparent Descriptions of Fresh Tissue Sampling and Preclinical Model Quality. / Chang, Che Feng; Cai, Li; Wang, Jian.
In: Translational Stroke Research, Vol. 6, No. 5, 25.04.2015, p. 384-389.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Translational Intracerebral Hemorrhage
T2 - a Need for Transparent Descriptions of Fresh Tissue Sampling and Preclinical Model Quality
AU - Chang, Che Feng
AU - Cai, Li
AU - Wang, Jian
PY - 2015/4/25
Y1 - 2015/4/25
N2 - For years, strategies have been proposed to improve translational success in stroke research by improving the quality of animal studies. However, articles that report preclinical intracerebral hemorrhage (ICH) studies continue to lack adequate qualitative and quantitative descriptions of fresh brain tissue collection. They also tend to lack transparency about animal model quality. We conducted a systematic review of 82 ICH research articles to determine the level of detail reported for brain tissue collection. We found that only 24 (29 %) reported the volume, weight, or thickness of tissue collected and a specific description of the anatomical location. Thus, up to 71 % of preclinical ICH research articles did not properly define how fresh specimens were collected for biochemical measurements. Such omissions may impede reproducibility of results between laboratories. Although existing criteria have improved the quality of preclinical stroke studies, ICH researchers need to identify specific guidelines and strategies to avoid pitfalls, minimize bias, and increase reproducibility in this field.
AB - For years, strategies have been proposed to improve translational success in stroke research by improving the quality of animal studies. However, articles that report preclinical intracerebral hemorrhage (ICH) studies continue to lack adequate qualitative and quantitative descriptions of fresh brain tissue collection. They also tend to lack transparency about animal model quality. We conducted a systematic review of 82 ICH research articles to determine the level of detail reported for brain tissue collection. We found that only 24 (29 %) reported the volume, weight, or thickness of tissue collected and a specific description of the anatomical location. Thus, up to 71 % of preclinical ICH research articles did not properly define how fresh specimens were collected for biochemical measurements. Such omissions may impede reproducibility of results between laboratories. Although existing criteria have improved the quality of preclinical stroke studies, ICH researchers need to identify specific guidelines and strategies to avoid pitfalls, minimize bias, and increase reproducibility in this field.
KW - Basic science
KW - Hematoma
KW - Intracerebral hemorrhage
KW - Multidisciplinary collaboration
KW - Preclinical criteria
KW - Translational stroke research
UR - http://www.scopus.com/inward/record.url?scp=84941187764&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84941187764&partnerID=8YFLogxK
U2 - 10.1007/s12975-015-0399-5
DO - 10.1007/s12975-015-0399-5
M3 - Article
VL - 6
SP - 384
EP - 389
JO - Translational Stroke Research
JF - Translational Stroke Research
SN - 1868-4483
IS - 5
ER -