Translational approaches for pharmacotherapy development for acute diarrhea

Mark Donowitz, David H. Alpers, Henry J. Binder, Thomas Brewer, Jill Carrington, Michael J. Grey

Research output: Contribution to journalArticle

Original languageEnglish (US)
JournalGastroenterology
Volume142
Issue number3
DOIs
StatePublished - Mar 2012

Keywords

  • adenosine 3′,5′-cyclic monophosphate
  • AQP
  • aquaporins
  • CaCC
  • calcium-activated Cl channels
  • calcium-sensing receptor
  • cAMP
  • CaSR
  • CFTR
  • cGMP
  • cystic fibrosis transmembrane conductance regulator
  • down-regulated in adenoma
  • DRA
  • ENaC
  • ENS
  • enteric nervous system
  • Epac
  • epithelial Na channel
  • exchange protein directly activated by cAMP
  • gastrointestinal
  • GC-C
  • GI
  • guanosine 3′,5′-cyclic monophosphate
  • guanylyl cyclase C
  • Kcnma1
  • large conductance, Ca -activated K channel
  • LPA
  • lysophosphatidic acid
  • MLCK
  • myosin light chain kinase
  • Na /H exchanger 2, SLC9A2
  • Na /H exchanger regulatory factor 1-4
  • Na /glucose cotransporter 1, SLC5A1
  • Na /H exchanger 3, SLC9A3
  • Na /H exchanger 8, SLC9A8
  • NHE2
  • NHE3
  • NHE8
  • NHERF1-4
  • oral rehydration solution
  • ORS
  • PKA
  • protein kinase A
  • SGLT1
  • signal transducer and activator of transcription
  • STAT
  • TNF
  • tumor necrosis factor

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Translational approaches for pharmacotherapy development for acute diarrhea. / Donowitz, Mark; Alpers, David H.; Binder, Henry J.; Brewer, Thomas; Carrington, Jill; Grey, Michael J.

In: Gastroenterology, Vol. 142, No. 3, 03.2012.

Research output: Contribution to journalArticle

Donowitz, Mark ; Alpers, David H. ; Binder, Henry J. ; Brewer, Thomas ; Carrington, Jill ; Grey, Michael J. / Translational approaches for pharmacotherapy development for acute diarrhea. In: Gastroenterology. 2012 ; Vol. 142, No. 3.
@article{d0345bce53604a54bd15614282c511b5,
title = "Translational approaches for pharmacotherapy development for acute diarrhea",
keywords = "adenosine 3′,5′-cyclic monophosphate, AQP, aquaporins, CaCC, calcium-activated Cl channels, calcium-sensing receptor, cAMP, CaSR, CFTR, cGMP, cystic fibrosis transmembrane conductance regulator, down-regulated in adenoma, DRA, ENaC, ENS, enteric nervous system, Epac, epithelial Na channel, exchange protein directly activated by cAMP, gastrointestinal, GC-C, GI, guanosine 3′,5′-cyclic monophosphate, guanylyl cyclase C, Kcnma1, large conductance, Ca -activated K channel, LPA, lysophosphatidic acid, MLCK, myosin light chain kinase, Na /H exchanger 2, SLC9A2, Na /H exchanger regulatory factor 1-4, Na /glucose cotransporter 1, SLC5A1, Na /H exchanger 3, SLC9A3, Na /H exchanger 8, SLC9A8, NHE2, NHE3, NHE8, NHERF1-4, oral rehydration solution, ORS, PKA, protein kinase A, SGLT1, signal transducer and activator of transcription, STAT, TNF, tumor necrosis factor",
author = "Mark Donowitz and Alpers, {David H.} and Binder, {Henry J.} and Thomas Brewer and Jill Carrington and Grey, {Michael J.}",
year = "2012",
month = "3",
doi = "10.1053/j.gastro.2012.01.014",
language = "English (US)",
volume = "142",
journal = "Gastroenterology",
issn = "0016-5085",
publisher = "W.B. Saunders Ltd",
number = "3",

}

TY - JOUR

T1 - Translational approaches for pharmacotherapy development for acute diarrhea

AU - Donowitz, Mark

AU - Alpers, David H.

AU - Binder, Henry J.

AU - Brewer, Thomas

AU - Carrington, Jill

AU - Grey, Michael J.

PY - 2012/3

Y1 - 2012/3

KW - adenosine 3′,5′-cyclic monophosphate

KW - AQP

KW - aquaporins

KW - CaCC

KW - calcium-activated Cl channels

KW - calcium-sensing receptor

KW - cAMP

KW - CaSR

KW - CFTR

KW - cGMP

KW - cystic fibrosis transmembrane conductance regulator

KW - down-regulated in adenoma

KW - DRA

KW - ENaC

KW - ENS

KW - enteric nervous system

KW - Epac

KW - epithelial Na channel

KW - exchange protein directly activated by cAMP

KW - gastrointestinal

KW - GC-C

KW - GI

KW - guanosine 3′,5′-cyclic monophosphate

KW - guanylyl cyclase C

KW - Kcnma1

KW - large conductance, Ca -activated K channel

KW - LPA

KW - lysophosphatidic acid

KW - MLCK

KW - myosin light chain kinase

KW - Na /H exchanger 2, SLC9A2

KW - Na /H exchanger regulatory factor 1-4

KW - Na /glucose cotransporter 1, SLC5A1

KW - Na /H exchanger 3, SLC9A3

KW - Na /H exchanger 8, SLC9A8

KW - NHE2

KW - NHE3

KW - NHE8

KW - NHERF1-4

KW - oral rehydration solution

KW - ORS

KW - PKA

KW - protein kinase A

KW - SGLT1

KW - signal transducer and activator of transcription

KW - STAT

KW - TNF

KW - tumor necrosis factor

UR - http://www.scopus.com/inward/record.url?scp=84857548490&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84857548490&partnerID=8YFLogxK

U2 - 10.1053/j.gastro.2012.01.014

DO - 10.1053/j.gastro.2012.01.014

M3 - Article

C2 - 22266149

AN - SCOPUS:84857548490

VL - 142

JO - Gastroenterology

JF - Gastroenterology

SN - 0016-5085

IS - 3

ER -