Translation elongation and recoding in eukaryotes

Thomas E. Dever, Jonathan D. Dinman, Rachel Green

Research output: Contribution to journalArticle

Abstract

In this review, we highlight the current understanding of translation elongation and recoding in eukaryotes. In addition to providing an overview of the process, recent advances in our understanding of the role of the factor eIF5A in both translation elongation and termination are discussed. We also highlight mechanisms of translation recoding with a focus on ribosomal frameshifting during elongation. We see that the balance between the basic steps in elongation and the less common recoding events is determined by the kinetics of the different processes as well as by specific sequence determinants.

Original languageEnglish (US)
Article numbera032649
JournalCold Spring Harbor Perspectives in Biology
Volume10
Issue number8
DOIs
StatePublished - Aug 1 2018

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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