Translation drives mRNA quality control

Christopher J. Shoemaker, Rachel Green

Research output: Contribution to journalArticle

Abstract

There are three predominant forms of co-translational mRNA surveillance: nonsense-mediated decay (NMD), no-go decay (NGD) and nonstop decay (NSD). Although discussion of these pathways often focuses on mRNA fate, there is growing consensus that there are other important outcomes of these processes that must be simultaneously considered. Here, we seek to highlight similarities between NMD, NGD and NSD and their probable origins on the ribosome during translation.

Original languageEnglish (US)
Pages (from-to)594-601
Number of pages8
JournalNature structural & molecular biology
Volume19
Issue number6
DOIs
StatePublished - Jun 2012

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Nonsense Mediated mRNA Decay
Protein Biosynthesis
Ribosomes
Quality Control
Messenger RNA

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology

Cite this

Translation drives mRNA quality control. / Shoemaker, Christopher J.; Green, Rachel.

In: Nature structural & molecular biology, Vol. 19, No. 6, 06.2012, p. 594-601.

Research output: Contribution to journalArticle

Shoemaker, Christopher J. ; Green, Rachel. / Translation drives mRNA quality control. In: Nature structural & molecular biology. 2012 ; Vol. 19, No. 6. pp. 594-601.
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