Translation drives mRNA quality control

Christopher J. Shoemaker, Rachel Green

Research output: Contribution to journalReview article


There are three predominant forms of co-translational mRNA surveillance: nonsense-mediated decay (NMD), no-go decay (NGD) and nonstop decay (NSD). Although discussion of these pathways often focuses on mRNA fate, there is growing consensus that there are other important outcomes of these processes that must be simultaneously considered. Here, we seek to highlight similarities between NMD, NGD and NSD and their probable origins on the ribosome during translation.

Original languageEnglish (US)
Pages (from-to)594-601
Number of pages8
JournalNature Structural and Molecular Biology
Issue number6
StatePublished - Jun 1 2012

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology

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