Transient uptake of serotonin by newborn olfactory projection neurons

B. S. Beltz, J. L. Benton, J. M. Sullivan

Research output: Contribution to journalArticlepeer-review

Abstract

A life-long turnover of sensory and interneuronal populations has been documented in the olfactory pathways of both vertebrates and invertebrates, creating a situation where the axons of new afferent and interneuronal populations must insert into a highly specialized glomerular neuropil. A dense serotonergic innervation of the primary olfactory processing areas where these neurons synapse also is a consistent feature across species. Prior studies in lobsters have shown that serotonin promotes the branching of olfactory projection neurons. This paper presents evidence that serotonin also regulates the proliferation and survival of projection neurons in lobsters, and that the serotonergic effects are associated with a transient uptake of serotonin into newborn neurons.

Original languageEnglish (US)
Pages (from-to)12730-12735
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume98
Issue number22
DOIs
StatePublished - Oct 23 2001
Externally publishedYes

ASJC Scopus subject areas

  • General

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