Transient postnatal elevation of serotonin levels in mouse neocortex

Christine F. Hohmann; Richard Hamon; Mark L. Batshaw; J. T. Coyle

doi:10.1016/0165-3806(88)90163-0

Transient postnatal elevation of serotonin levels in mouse neocortex

Christine F. Hohmann, Richard Hamon, Mark L. Batshaw, J. T. Coyle

School of Medicine

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

Serotonin (5-HT), norepinephrine (NE) and 5-hydroxyindoleacetic acid (HIAA) levels were measured during ontogeny of frontoparietal cortex in Balb/C mice by high-pressure liquid chromatography (HPLC) with electrochemical detection. Unlike NE, the concentration of 5-HT was transiently elevated to more than twice the adult level during the first postnatal week; this was accompanied by increased HIAA content comparable to the adult, indicating elevated levels of 5-HT release. Since a transient hyperplasia of 5-HT-immunoreactive fibers and uptake sites has been observed previously in the same cortical areas, the transient elevation of 5-HT levels may play an important role in shaping early postnatal morphogenetic events in neocortex.

Original language	English (US)
Pages (from-to)	163-166
Number of pages	4
Journal	Developmental Brain Research
Volume	43
Issue number	1
DOIs	https://doi.org/10.1016/0165-3806(88)90163-0
State	Published - Sep 1 1988

Keywords

Development
Mouse
Neocortex
Noradrenaline
Serotonin

ASJC Scopus subject areas

Developmental Neuroscience
Developmental Biology

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10.1016/0165-3806(88)90163-0

Cite this

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title = "Transient postnatal elevation of serotonin levels in mouse neocortex",

abstract = "Serotonin (5-HT), norepinephrine (NE) and 5-hydroxyindoleacetic acid (HIAA) levels were measured during ontogeny of frontoparietal cortex in Balb/C mice by high-pressure liquid chromatography (HPLC) with electrochemical detection. Unlike NE, the concentration of 5-HT was transiently elevated to more than twice the adult level during the first postnatal week; this was accompanied by increased HIAA content comparable to the adult, indicating elevated levels of 5-HT release. Since a transient hyperplasia of 5-HT-immunoreactive fibers and uptake sites has been observed previously in the same cortical areas, the transient elevation of 5-HT levels may play an important role in shaping early postnatal morphogenetic events in neocortex.",

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author = "Hohmann, {Christine F.} and Richard Hamon and Batshaw, {Mark L.} and Coyle, {J. T.}",

note = "Funding Information: We thank Alice Trawinski for assistance in preparation of this manuscript. This work was supported by USPHS Grant NS 18414.",

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T1 - Transient postnatal elevation of serotonin levels in mouse neocortex

AU - Hohmann, Christine F.

AU - Hamon, Richard

AU - Batshaw, Mark L.

AU - Coyle, J. T.

N1 - Funding Information: We thank Alice Trawinski for assistance in preparation of this manuscript. This work was supported by USPHS Grant NS 18414.

PY - 1988/9/1

Y1 - 1988/9/1

N2 - Serotonin (5-HT), norepinephrine (NE) and 5-hydroxyindoleacetic acid (HIAA) levels were measured during ontogeny of frontoparietal cortex in Balb/C mice by high-pressure liquid chromatography (HPLC) with electrochemical detection. Unlike NE, the concentration of 5-HT was transiently elevated to more than twice the adult level during the first postnatal week; this was accompanied by increased HIAA content comparable to the adult, indicating elevated levels of 5-HT release. Since a transient hyperplasia of 5-HT-immunoreactive fibers and uptake sites has been observed previously in the same cortical areas, the transient elevation of 5-HT levels may play an important role in shaping early postnatal morphogenetic events in neocortex.

AB - Serotonin (5-HT), norepinephrine (NE) and 5-hydroxyindoleacetic acid (HIAA) levels were measured during ontogeny of frontoparietal cortex in Balb/C mice by high-pressure liquid chromatography (HPLC) with electrochemical detection. Unlike NE, the concentration of 5-HT was transiently elevated to more than twice the adult level during the first postnatal week; this was accompanied by increased HIAA content comparable to the adult, indicating elevated levels of 5-HT release. Since a transient hyperplasia of 5-HT-immunoreactive fibers and uptake sites has been observed previously in the same cortical areas, the transient elevation of 5-HT levels may play an important role in shaping early postnatal morphogenetic events in neocortex.

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KW - Mouse

KW - Neocortex

KW - Noradrenaline

KW - Serotonin

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Transient postnatal elevation of serotonin levels in mouse neocortex

Abstract

Keywords

ASJC Scopus subject areas

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