Transient postnatal elevation of serotonin levels in mouse neocortex

Christine F. Hohmann, Richard Hamon, Mark L. Batshaw, J. T. Coyle

Research output: Contribution to journalArticlepeer-review

Abstract

Serotonin (5-HT), norepinephrine (NE) and 5-hydroxyindoleacetic acid (HIAA) levels were measured during ontogeny of frontoparietal cortex in Balb/C mice by high-pressure liquid chromatography (HPLC) with electrochemical detection. Unlike NE, the concentration of 5-HT was transiently elevated to more than twice the adult level during the first postnatal week; this was accompanied by increased HIAA content comparable to the adult, indicating elevated levels of 5-HT release. Since a transient hyperplasia of 5-HT-immunoreactive fibers and uptake sites has been observed previously in the same cortical areas, the transient elevation of 5-HT levels may play an important role in shaping early postnatal morphogenetic events in neocortex.

Original languageEnglish (US)
Pages (from-to)163-166
Number of pages4
JournalDevelopmental Brain Research
Volume43
Issue number1
DOIs
StatePublished - Sep 1 1988

Keywords

  • Development
  • Mouse
  • Neocortex
  • Noradrenaline
  • Serotonin

ASJC Scopus subject areas

  • Developmental Neuroscience
  • Developmental Biology

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