Transient Migratory Osteoporosis in Osteogenesis Imperfecta

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Transient or transient migratory osteoporosis (TMO) is a painful and disabling disorder that occurs in patients with osteogenesis imperfecta. TMO is probably under-reported. TMO frequently affects men over the age of 40 or women in the late prenatal period of pregnancy or postpartum. In the individual with OI this diagnosis may be more difficult to determine because of bone deformity or pre-existent microfractures. T2-weighted MRI imaging may be diagnostic. Diagnostic confusion with other entities such as inflammatory arthropathy or avascular necrosis can lead to inappropriate treatment. The etiology of TMO is not defined; however, a cellular inflammatory response to microfractures may be causative. A limited number of studies, mainly involving single case reports, suggest that compared to conservative therapy, treatment with bisphosphonates may speed resolution and normalization of MRI changes. The prostaglandin analog ioprost may also be effective. TMO should be considered in the OI patient with rapid onset hip pain if fracture is excluded by radiologic procedures.

Original languageEnglish (US)
Title of host publicationOsteogenesis Imperfecta: A Translational Approach to Brittle Bone Disease
PublisherElsevier Inc.
Pages359-370
Number of pages12
ISBN (Print)9780123971654
DOIs
StatePublished - Sep 2013

Fingerprint

Osteogenesis Imperfecta
Osteoporosis
Stress Fractures
Synthetic Prostaglandins
Joint Diseases
Hip Fractures
Diphosphonates
Postpartum Period
Necrosis
Bone and Bones
Pain
Pregnancy

Keywords

  • Osteogenesis imperfecta (OI)
  • Pregnancy
  • Transient migratory osteoporosis (TMO)

ASJC Scopus subject areas

  • Medicine(all)
  • Dentistry(all)

Cite this

Shapiro, J. (2013). Transient Migratory Osteoporosis in Osteogenesis Imperfecta. In Osteogenesis Imperfecta: A Translational Approach to Brittle Bone Disease (pp. 359-370). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-397165-4.00039-3

Transient Migratory Osteoporosis in Osteogenesis Imperfecta. / Shapiro, Jay.

Osteogenesis Imperfecta: A Translational Approach to Brittle Bone Disease. Elsevier Inc., 2013. p. 359-370.

Research output: Chapter in Book/Report/Conference proceedingChapter

Shapiro, J 2013, Transient Migratory Osteoporosis in Osteogenesis Imperfecta. in Osteogenesis Imperfecta: A Translational Approach to Brittle Bone Disease. Elsevier Inc., pp. 359-370. https://doi.org/10.1016/B978-0-12-397165-4.00039-3
Shapiro J. Transient Migratory Osteoporosis in Osteogenesis Imperfecta. In Osteogenesis Imperfecta: A Translational Approach to Brittle Bone Disease. Elsevier Inc. 2013. p. 359-370 https://doi.org/10.1016/B978-0-12-397165-4.00039-3
Shapiro, Jay. / Transient Migratory Osteoporosis in Osteogenesis Imperfecta. Osteogenesis Imperfecta: A Translational Approach to Brittle Bone Disease. Elsevier Inc., 2013. pp. 359-370
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