Transient lesion in the splenium of the corpus callosum in acute uncomplicated falciparum malaria

Jiraporn Laothamatas, Christina L. Sammet, Xavier Golay, Marc Van Cauteren, Varinee Lekprasert, Noppadon Tangpukdee, Srivicha Krudsood, Wattana Leowattana, Polrat Wilairatana, Srirama V. Swaminathan, Robert L. DeLaPaz, Truman R. Brown, Sornchai Looareesuwan, Gary M. Brittenham

Research output: Contribution to journalArticlepeer-review

Abstract

Patients with acute uncomplicated Plasmodium falciparum malaria have no evident neurologic disorder, vital organ dysfunction, or other severe manifestations of infection. Nonetheless, parasitized erythrocytes cytoadhere to the endothelium throughout their microvasculature, especially within the brain. We aimed to determine if 3 Tesla magnetic resonance imaging studies could detect evidence of cerebral abnormalities in these patients. Within 24 hours of admission, initial magnetic resonance imaging examinations found a lesion with restricted water diffusion in the mid-portion of the splenium of the corpus callosum of 4 (40%) of 10 male patients. The four patients who had a splenial lesion initially had evidence of more severe hemolysis and thrombocytopenia than the six patients who had no apparent abnormality. Repeat studies four weeks later found no residua of the lesions and resolution of the hematologic differences. These observations provide evidence for acute cerebral injury in the absence of severe or cerebral malaria.

Original languageEnglish (US)
Pages (from-to)1117-1123
Number of pages7
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume90
Issue number6
DOIs
StatePublished - Jun 2014

ASJC Scopus subject areas

  • Parasitology
  • Virology
  • Infectious Diseases

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