Transient global amnesia: A study with Tc-99m ecd spect shortly after symptom onset and after recovery

Bom Sahn Kim, Sang Soo Cho, Joon Young Choi, Young Hwan Kim

Research output: Contribution to journalArticlepeer-review

Abstract

PURPOSE Transient global amnesia (TGA) is characterized by sudden loss of memory of recent events, transient inability to retain new information, and retrograde amnesia. We investigated the changes of regional cerebral blood flow in patients with TGA shortly after symptom onset and after recovery using Tc-99m-ethyl cysteinate dimer single-photon emission computed tomography (Tc-99m ECD SPECT) and statistical parametric mapping (SPM) analysis. METHODS Six right-handed patients with TGA were studied using Tc-99m ECD SPECT shortly after symptom onset and after recovery. As a control group, six healthy individuals were also studied. Images were analyzed using SPM8 using voxel-based analysis to estimate the differences between TGA patients and controls. RESULTS There was significant hypoperfusion in the left hippocampus, left thalamus, and bilateral cerebellum. In the follow-up SPECT scan, hypoperfusion in hippocampus and thalamus were restored, while hypoperfusion was noted in the temporoparietal region. CONCLUSION Our results suggest that the underlying mechanism of TGA may be temporary ischemia in the hippocampus and thalamus. There was significant restoration of perfusion in the hippocampus and thalamus after recovery from TGA.

Original languageEnglish (US)
Pages (from-to)476-480
Number of pages5
JournalDiagnostic and Interventional Radiology
Volume22
Issue number5
DOIs
StatePublished - Sep 2016

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Fingerprint

Dive into the research topics of 'Transient global amnesia: A study with Tc-99m ecd spect shortly after symptom onset and after recovery'. Together they form a unique fingerprint.

Cite this