Transient down-regulation of inhibin-βC expression following partial hepatectomy

Aurora F. Esquela, Teresa A. Zimmers, Leonidas G. Koniaris, James V. Sitzmann, Se Jin Lee

Research output: Contribution to journalArticlepeer-review

35 Scopus citations


Inhibin-βC is a recently described TGF-β family member most homologous to inhibin-βA and inhibin-βB. By Northern analysis, inhibin-βC mRNA was detected exclusively in the liver among a large number of adult mouse tissues surveyed. The expression of inhibin-βC mRNA in adult liver dropped sharply and transiently following partial hepatectomy. At 6 and 12 hours following partial hepatectomy, the levels of inhibin-βC mRNA were at least 8-fold lower than in control animals. The liver specificity of inhibin-βC expression and its down-regulation following partial hepatectomy suggest that inhibin-βC may function as a negative regulator of liver growth.

Original languageEnglish (US)
Pages (from-to)553-556
Number of pages4
JournalBiochemical and Biophysical Research Communications
Issue number3
StatePublished - Jun 27 1997
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology


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