TY - JOUR
T1 - Transient docking of synaptic vesicles
T2 - Implications and mechanisms
AU - Kusick, Grant F.
AU - Ogunmowo, Tyler H.
AU - Watanabe, Shigeki
N1 - Publisher Copyright:
© 2022 The Author(s)
PY - 2022/6
Y1 - 2022/6
N2 - As synaptic vesicles fuse, they must continually be replaced with new docked, fusion-competent vesicles to sustain neurotransmission. It has long been appreciated that vesicles are recruited to docking sites in an activity-dependent manner. However, once entering the sites, vesicles were thought to be stably docked, awaiting calcium signals. Based on recent data from electrophysiology, electron microscopy, biochemistry, and computer simulations, a picture emerges in which vesicles can rapidly and reversibly transit between docking and undocking during activity. This “transient docking” can account for many aspects of synaptic physiology. In this review, we cover recent evidence for transient docking, physiological processes at the synapse that it may support, and progress on the underlying mechanisms.
AB - As synaptic vesicles fuse, they must continually be replaced with new docked, fusion-competent vesicles to sustain neurotransmission. It has long been appreciated that vesicles are recruited to docking sites in an activity-dependent manner. However, once entering the sites, vesicles were thought to be stably docked, awaiting calcium signals. Based on recent data from electrophysiology, electron microscopy, biochemistry, and computer simulations, a picture emerges in which vesicles can rapidly and reversibly transit between docking and undocking during activity. This “transient docking” can account for many aspects of synaptic physiology. In this review, we cover recent evidence for transient docking, physiological processes at the synapse that it may support, and progress on the underlying mechanisms.
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U2 - 10.1016/j.conb.2022.102535
DO - 10.1016/j.conb.2022.102535
M3 - Review article
C2 - 35398664
AN - SCOPUS:85128822387
SN - 0959-4388
VL - 74
JO - Current Opinion in Neurobiology
JF - Current Opinion in Neurobiology
M1 - 102535
ER -