TY - JOUR
T1 - Transient cortical circuits match spontaneous and sensory-driven activity during development
AU - Molnár, Zoltán
AU - Luhmann, Heiko J.
AU - Kanold, Patrick O.
N1 - Funding Information:
P.O.K. is supported by NIH R01DC009607. H.J.L. is supported by Deutsche Forschungsgemeinschaft (SFB1080-A01). Work in Z.M.'s laboratory is supported by the MRC, Royal Society, and Oxford Martin School. Z.M. is an Einstein Visiting Fellow at Charité-Universitätsmedizin Berlin, Cluster of Excellence NeuroCure and Institute of Biochemistry.
Publisher Copyright:
© 2020 American Association for the Advancement of Science. All rights reserved.
PY - 2020/10/16
Y1 - 2020/10/16
N2 - At the earliest developmental stages, spontaneous activity synchronizes local and large-scale cortical networks. These networks form the functional template for the establishment of global thalamocortical networks and cortical architecture. The earliest connections are established autonomously. However, activity from the sensory periphery reshapes these circuits as soon as afferents reach the cortex. The early-generated, largely transient neurons of the subplate play a key role in integrating spontaneous and sensory-driven activity. Early pathological conditions-such as hypoxia, inflammation, or exposure to pharmacological compounds-alter spontaneous activity patterns, which subsequently induce disturbances in cortical network activity. This cortical dysfunction may lead to local and global miswiring and, at later stages, can be associated with neurological and psychiatric conditions.
AB - At the earliest developmental stages, spontaneous activity synchronizes local and large-scale cortical networks. These networks form the functional template for the establishment of global thalamocortical networks and cortical architecture. The earliest connections are established autonomously. However, activity from the sensory periphery reshapes these circuits as soon as afferents reach the cortex. The early-generated, largely transient neurons of the subplate play a key role in integrating spontaneous and sensory-driven activity. Early pathological conditions-such as hypoxia, inflammation, or exposure to pharmacological compounds-alter spontaneous activity patterns, which subsequently induce disturbances in cortical network activity. This cortical dysfunction may lead to local and global miswiring and, at later stages, can be associated with neurological and psychiatric conditions.
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U2 - 10.1126/science.abb2153
DO - 10.1126/science.abb2153
M3 - Review article
C2 - 33060328
AN - SCOPUS:85093486222
SN - 0036-8075
VL - 370
JO - Science
JF - Science
IS - 6514
M1 - abb2153
ER -