Transgenic mouse models of neurodegenerative disease: opportunities for therapeutic development.

Joanna L. Jankowsky, Alena Savonenko, Gabriele Schilling, Jiou Wang, Guilian Xu, David R. Borchelt

Research output: Contribution to journalReview articlepeer-review

Abstract

Neurodegenerative diseases present an extraordinary challenge for medicine due to the grave nature of these illnesses, their prevalence, and their impact on individuals and caregivers. The most common of these age-associated chronic illnesses are Alzheimer's disease (AD) and Parkinson's disease (PD); other examples include the prion disorders, amyotrophic lateral sclerosis (ALS), and the trinucleotide (CAG) repeat diseases. All of these diseases are characterized by well-defined clinical syndromes with progressive courses that reflect the dysfunction and eventual loss of specific neuronal populations. Current therapies provide only symptomatic relief; none significantly alter the course of disease. We describe here how transgenic mice designed to model these diseases have substantially contributed to the identification and validation of many promising new therapies, and conversely how they have quickly and cost effectively eliminated several targets with unrealized expectations.

Original languageEnglish (US)
Pages (from-to)457-464
Number of pages8
JournalCurrent neurology and neuroscience reports
Volume2
Issue number5
DOIs
StatePublished - Sep 2002

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

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