Transgenic mouse models of Alzheimer's disease and amyotrophic lateral sclerosis

David R. Borchelt, Philip Chun Wong, Sangram S. Sisodia, Donald L. Price

Research output: Contribution to journalArticle

Abstract

Over the past several years, there has been enormous progress in generating transgenic mice that model aspects of human neurodegenerative diseases. These studies build upon the efforts of molecular geneticists who have identified a number of genes that, when mutated, cause familial forms of these diseases. In this review, we focus on the mutations that cause familial forms of Alzheimer's disease (AD) and amyotrophic lateral sclerosis (ALS), and transgenic mouse models that develop clinical and pathological abnormalities resembling those occurring in the human diseases.

Original languageEnglish (US)
Pages (from-to)735-757
Number of pages23
JournalBrain Pathology
Volume8
Issue number4
StatePublished - 1998

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Amyotrophic Lateral Sclerosis
Transgenic Mice
Alzheimer Disease
Neurodegenerative Diseases
Mutation
Genes

ASJC Scopus subject areas

  • Neuroscience(all)
  • Pathology and Forensic Medicine

Cite this

Borchelt, D. R., Wong, P. C., Sisodia, S. S., & Price, D. L. (1998). Transgenic mouse models of Alzheimer's disease and amyotrophic lateral sclerosis. Brain Pathology, 8(4), 735-757.

Transgenic mouse models of Alzheimer's disease and amyotrophic lateral sclerosis. / Borchelt, David R.; Wong, Philip Chun; Sisodia, Sangram S.; Price, Donald L.

In: Brain Pathology, Vol. 8, No. 4, 1998, p. 735-757.

Research output: Contribution to journalArticle

Borchelt, DR, Wong, PC, Sisodia, SS & Price, DL 1998, 'Transgenic mouse models of Alzheimer's disease and amyotrophic lateral sclerosis', Brain Pathology, vol. 8, no. 4, pp. 735-757.
Borchelt, David R. ; Wong, Philip Chun ; Sisodia, Sangram S. ; Price, Donald L. / Transgenic mouse models of Alzheimer's disease and amyotrophic lateral sclerosis. In: Brain Pathology. 1998 ; Vol. 8, No. 4. pp. 735-757.
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