Transgenic mouse models of Alzheimer's disease and amyotrophic lateral sclerosis

David R. Borchelt, Philip C. Wong, Sangram S. Sisodia, Donald L. Price

Research output: Contribution to journalArticlepeer-review

Abstract

Over the past several years, there has been enormous progress in generating transgenic mice that model aspects of human neurodegenerative diseases. These studies build upon the efforts of molecular geneticists who have identified a number of genes that, when mutated, cause familial forms of these diseases. In this review, we focus on the mutations that cause familial forms of Alzheimer's disease (AD) and amyotrophic lateral sclerosis (ALS), and transgenic mouse models that develop clinical and pathological abnormalities resembling those occurring in the human diseases.

Original languageEnglish (US)
Pages (from-to)735-757
Number of pages23
JournalBrain Pathology
Volume8
Issue number4
DOIs
StatePublished - 1998

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Neuroscience(all)
  • Clinical Neurology

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