TY - JOUR
T1 - Transgenic mouse model of stunned myocardium
AU - Murphy, Anne M.
AU - Kögler, Harald
AU - Georgakopoulos, Dimitrios
AU - McDonough, Jason L.
AU - Kass, David A.
AU - Van Eyk, Jennifer E.
AU - Marbán, Eduardo
N1 - Copyright:
Copyright 2007 Elsevier B.V., All rights reserved.
PY - 2000/1/21
Y1 - 2000/1/21
N2 - Stunned myocardium is a syndrome of reversible contractile failure that frequently complicates coronary artery disease. Cardiac excitation is uncoupled from contraction at the level of the myofilaments. Selective proteolysis of the thin filament protein troponin I has been correlated with stunned myocardium. Here, transgenic mice expressing the major degradation product of troponin I (TnI1-193) in the heart were found to develop ventricular dilatation, diminished contractility, and reduced myofilament calcium responsiveness, recapitulating the phenotype of stunned myocardium. Proteolysis of troponin I also occurs in ischemic human cardiac muscle. Thus, troponin I proteolysis underlies the pathogenesis of a common acquired form of heart failure.
AB - Stunned myocardium is a syndrome of reversible contractile failure that frequently complicates coronary artery disease. Cardiac excitation is uncoupled from contraction at the level of the myofilaments. Selective proteolysis of the thin filament protein troponin I has been correlated with stunned myocardium. Here, transgenic mice expressing the major degradation product of troponin I (TnI1-193) in the heart were found to develop ventricular dilatation, diminished contractility, and reduced myofilament calcium responsiveness, recapitulating the phenotype of stunned myocardium. Proteolysis of troponin I also occurs in ischemic human cardiac muscle. Thus, troponin I proteolysis underlies the pathogenesis of a common acquired form of heart failure.
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U2 - 10.1126/science.287.5452.488
DO - 10.1126/science.287.5452.488
M3 - Article
C2 - 10642551
AN - SCOPUS:17944384116
SN - 0036-8075
VL - 287
SP - 488
EP - 491
JO - Science
JF - Science
IS - 5452
ER -