Mosquitos transgênicos para o controle da malária: Progressos e desafios

Translated title of the contribution: Transgenic mosquitoes for malaria control: Progresses and challenges

Luciano A. Moreira, Marcelo Jacobs-Lorena

Research output: Contribution to journalArticle

Abstract

Malaria kills millions of people every year and the current strategies to control the disease, such as insecticides and drugs have not been completely efficient. Because of that, novel means to fight against malaria are of utmost importance. Advances in the study of the mosquito vector and its interactions with the malaria parasite made scientists think that it is possible to genetically manipulate the mosquitoes to make them inefficient vectors. Here we review the advances on the introduction of foreign genes into the mosquito germ line, the characterization of tissue-specific promoters, the identification of gene products that block development of the parasite in the mosquito, and we discuss the recent generation of transgenic mosquitoes impaired for malaria transmission. While much progress has been made, many years of research are still needed before transgenic mosquitoes can be used in the field.

Original languagePortuguese
Pages (from-to)531-536
Number of pages6
JournalNeotropical Entomology
Volume32
Issue number4
StatePublished - 2003

Fingerprint

malaria
Culicidae
genetically modified organisms
parasites
product development
germ cells
disease control
insecticides
genes
promoter regions
drugs

Keywords

  • Malaria
  • Plasmodium
  • Transgenesis
  • Transmission blocking

ASJC Scopus subject areas

  • Insect Science

Cite this

Mosquitos transgênicos para o controle da malária : Progressos e desafios. / Moreira, Luciano A.; Jacobs-Lorena, Marcelo.

In: Neotropical Entomology, Vol. 32, No. 4, 2003, p. 531-536.

Research output: Contribution to journalArticle

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