Transfusion of hemoglobin-based oxygen carriers in the carboxy state is beneficial during transient focal cerebral ischemia

Jian Zhang, Suyi Cao, Herman Kwansa, Daina Crafa, Kathleen K. Kibler, Raymond C Koehler

Research output: Contribution to journalArticle

Abstract

Exchange transfusion of large volumes of hemoglobin (Hb)-based oxygen carriers can protect the brain from middle cerebral artery occlusion (MCAO). Hb in the carboxy state (COHb) may provide protection at relatively low volumes by enhancing vasodilation. We determined whether transfusion of rats with 10 ml/kg PEGylated COHb [polyethylene glycol (PEG)-COHb] at 20 min of 2-h MCAO was more effective in reducing infarct volume compared with non-carbon monoxide (CO) PEG-Hb. After PEG-COHb transfusion, whole blood and plasma COHb was

Original languageEnglish (US)
Pages (from-to)1709-1717
Number of pages9
JournalJournal of Applied Physiology
Volume113
Issue number11
DOIs
StatePublished - Dec 1 2012

Fingerprint

Transient Ischemic Attack
Hemoglobins
Middle Cerebral Artery Infarction
Oxygen
Vasodilation
Brain

Keywords

  • Carbon monoxide
  • Cerebral blood flow
  • Pial artery
  • Rat
  • Stroke

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Transfusion of hemoglobin-based oxygen carriers in the carboxy state is beneficial during transient focal cerebral ischemia. / Zhang, Jian; Cao, Suyi; Kwansa, Herman; Crafa, Daina; Kibler, Kathleen K.; Koehler, Raymond C.

In: Journal of Applied Physiology, Vol. 113, No. 11, 01.12.2012, p. 1709-1717.

Research output: Contribution to journalArticle

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