Transforming growth factor beta stimulates phosphoinositol metabolism and translocation of protein kinase C in cultured astrocytes

Patricia L. Robertson, Jasna Markovac, Subhash C. Datta, Gary W. Goldstein

Research output: Contribution to journalArticlepeer-review

Abstract

Transforming growth factor beta (TGF-β) is a regulatory peptide found in many normal and neoplastic tissues, including brain, with a diverse range of cellular effects. The transmembrane biochemical signals by which TGF-β exerts these effects and the second messenger systems that may amplify them are unknown. We investigated the effects of TGF-β upon membrane phosphoinositol metabolism and protein kinase C activity in cultured astrocytes. We found that exposure of astrocyte enriched cultures to TGF-β resulted in the stimulation of phosphoinositol lipid turnover to inositol phosphates and in the apparent redistribution of protein kinase C from cytosol to membrane.

Original languageEnglish (US)
Pages (from-to)107-113
Number of pages7
JournalNeuroscience Letters
Volume93
Issue number1
DOIs
StatePublished - Oct 31 1988
Externally publishedYes

Keywords

  • Astrocyte
  • Phosphoinositol metabolism
  • Protein kinase C
  • Transforming growth factor beta

ASJC Scopus subject areas

  • Neuroscience(all)

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