Transforming growth factor-beta signaling in breast cancer

Ching Fang Chang, Reyhan Westbrook, Jun Ma, Deliang Cao

Research output: Contribution to journalReview article

Abstract

Transforming growth factor-β (TGF-β) is a multifunctional polypeptide that regulates cell growth, differentiation, and extracellular matrix formation. Studies on genetically engineered animal models have demonstrated that TGF-β-mediated signaling pathway plays a critical role in both normal development and tumorigenesis of the breast. In pathogenesis of breast cancer, the role of TGF-β appears featured with growthinhibitory effects at early stages of carcinogenesis, but aggressive oncogenesis with transition to more advanced malignant states. The TGF-β signaling pathway is also tissue-context and ligand content-dependent. Therein, therapeutic modulation of TGF-β signaling may be a multifactorial event.

Original languageEnglish (US)
Pages (from-to)4393-4401
Number of pages9
JournalFrontiers in Bioscience
Volume12
Issue number12
DOIs
StatePublished - May 1 2007
Externally publishedYes

Fingerprint

Transforming Growth Factors
Transforming Growth Factor beta
Breast Neoplasms
Carcinogenesis
Genetically Modified Animals
Cell growth
Extracellular Matrix
Cell Differentiation
Animals
Breast
Animal Models
Modulation
Tissue
Ligands
Peptides
Growth

Keywords

  • Animal model
  • Breast cancer
  • Cancer therapy
  • Mammary gland
  • Review
  • Smad protein
  • TGF-β ligand
  • TGF-β receptor
  • Tumor promotion
  • Tumor suppressor
  • Tumor-associated macrophages

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Cite this

Transforming growth factor-beta signaling in breast cancer. / Chang, Ching Fang; Westbrook, Reyhan; Ma, Jun; Cao, Deliang.

In: Frontiers in Bioscience, Vol. 12, No. 12, 01.05.2007, p. 4393-4401.

Research output: Contribution to journalReview article

Chang, Ching Fang ; Westbrook, Reyhan ; Ma, Jun ; Cao, Deliang. / Transforming growth factor-beta signaling in breast cancer. In: Frontiers in Bioscience. 2007 ; Vol. 12, No. 12. pp. 4393-4401.
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