Transforming growth factor-beta: A target for cancer therapy

Ronan J. Kelly; John C. Morris

doi:10.3109/15476910903389920

Transforming growth factor-beta: A target for cancer therapy

Ronan J. Kelly, John C. Morris

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

Transforming growth factor-beta (TGF-β) is a pleiotropic growth factor that regulates cell growth and differentiation, apoptosis, cell motility, extracellular matrix production, angiogenesis, and cellular immune responses. TGF-β demonstrates paradoxical action whereby it can function to suppress early tumorigenesis; however, it can also facilitate malignant transformation and stimulate tumor growth by manipulating a more hospitable environment for tumor invasion and the development of metastases. Given the integral role of TGF-β in transformation and cancer progression, various components of the TGF-β signaling pathway offer potentially attractive therapeutic targets for cancer treatment. This review focuses on the role of TGF-β in cancer and discusses both small and large molecule drugs currently in development that target TGF-β, its receptor and important down stream steps along its signaling pathway.

Original language	English (US)
Pages (from-to)	15-26
Number of pages	12
Journal	Journal of Immunotoxicology
Volume	7
Issue number	1
DOIs	https://doi.org/10.3109/15476910903389920
State	Published - Mar 2010
Externally published	Yes

Keywords

Betaglycan
Cancer
Receptor
Smad
Transforming growth factor-beta

ASJC Scopus subject areas

Immunology
Toxicology

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10.3109/15476910903389920

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title = "Transforming growth factor-beta: A target for cancer therapy",

abstract = "Transforming growth factor-beta (TGF-β) is a pleiotropic growth factor that regulates cell growth and differentiation, apoptosis, cell motility, extracellular matrix production, angiogenesis, and cellular immune responses. TGF-β demonstrates paradoxical action whereby it can function to suppress early tumorigenesis; however, it can also facilitate malignant transformation and stimulate tumor growth by manipulating a more hospitable environment for tumor invasion and the development of metastases. Given the integral role of TGF-β in transformation and cancer progression, various components of the TGF-β signaling pathway offer potentially attractive therapeutic targets for cancer treatment. This review focuses on the role of TGF-β in cancer and discusses both small and large molecule drugs currently in development that target TGF-β, its receptor and important down stream steps along its signaling pathway.",

keywords = "Betaglycan, Cancer, Receptor, Smad, Transforming growth factor-beta",

author = "Kelly, {Ronan J.} and Morris, {John C.}",

note = "Funding Information: This work was supported by the Intramural Research Program of the NIH, National Cancer Institute, Center for Cancer Research.",

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T2 - A target for cancer therapy

AU - Kelly, Ronan J.

AU - Morris, John C.

N1 - Funding Information: This work was supported by the Intramural Research Program of the NIH, National Cancer Institute, Center for Cancer Research.

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KW - Smad

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Transforming growth factor-beta: A target for cancer therapy

Abstract

Keywords

ASJC Scopus subject areas

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