TY - JOUR
T1 - Transforming growth factor-β1 rise in pleural fluid after tunneled pleural catheter placement pilot study
AU - Shojaee, Semira
AU - Voelkel, Norbert
AU - Farkas, Laszlo
AU - De Wit, Marjolein
AU - Lee, Hans J.
PY - 2013/10
Y1 - 2013/10
N2 - Background: Transforming growth factor-β1 (TGF-β1) plays a major role in pleural fibrosis and chemical pleurodesis. Approximately 50% of patients with tunneled pleural catheters (TPCs) for malignant pleural effusions (MPEs) will have autopleurodesis. Pleural TGF-β1 levels have never been measured in the setting of TPC drainage and may predict autopleurodesis. Methods: Pleural fluid was collected prospectively in subjects with MPE and planned TPC insertion. Pleural fluid was collected at time 0 (T0, thoracentecis before TPC placement), time 1 (T1, TPC insertion), and time 2 (T2, 2 wk after TPC insertion). The MPE levels of TGF-β1, vascular endothelial growth factor, and plasminogen activator inhibitor-1 were measured using ELISA. Lactate dehydrogenase levels were also measured at T0. Patients were followed up for autopleurodesis and TPC removal. Results: Nineteen samples were collected from 9 patients with MPE who underwent TPC placement. Three patients died before the study completion. The median level of TGF-β1 of 1243 pg/mL (range, 620 to 4547 pg/mL) at T1 in 6 patients showed a statistically significant rise to 2857 pg/mL (range, 2120 to 7160 pg/mL) after TPC placement (P=0.004, R2 = 0.898). There was no statistically significant increase in TGFβ1 levels from T0 to T1. There was a linear relationship between TGF-β1 and lactate dehydrogenase at T0 (R2 = 0.635). Plasminogen activator inhibitor-1 levels increased from T1 to T2, but was not statistically significant. There was no significant rise in vascular endothelial growth factor from T1 to T2. Conclusions: TPC insertion results in an independent increase in TGF-β1 levels in MPE.
AB - Background: Transforming growth factor-β1 (TGF-β1) plays a major role in pleural fibrosis and chemical pleurodesis. Approximately 50% of patients with tunneled pleural catheters (TPCs) for malignant pleural effusions (MPEs) will have autopleurodesis. Pleural TGF-β1 levels have never been measured in the setting of TPC drainage and may predict autopleurodesis. Methods: Pleural fluid was collected prospectively in subjects with MPE and planned TPC insertion. Pleural fluid was collected at time 0 (T0, thoracentecis before TPC placement), time 1 (T1, TPC insertion), and time 2 (T2, 2 wk after TPC insertion). The MPE levels of TGF-β1, vascular endothelial growth factor, and plasminogen activator inhibitor-1 were measured using ELISA. Lactate dehydrogenase levels were also measured at T0. Patients were followed up for autopleurodesis and TPC removal. Results: Nineteen samples were collected from 9 patients with MPE who underwent TPC placement. Three patients died before the study completion. The median level of TGF-β1 of 1243 pg/mL (range, 620 to 4547 pg/mL) at T1 in 6 patients showed a statistically significant rise to 2857 pg/mL (range, 2120 to 7160 pg/mL) after TPC placement (P=0.004, R2 = 0.898). There was no statistically significant increase in TGFβ1 levels from T0 to T1. There was a linear relationship between TGF-β1 and lactate dehydrogenase at T0 (R2 = 0.635). Plasminogen activator inhibitor-1 levels increased from T1 to T2, but was not statistically significant. There was no significant rise in vascular endothelial growth factor from T1 to T2. Conclusions: TPC insertion results in an independent increase in TGF-β1 levels in MPE.
KW - Malignant pleural effusions
KW - Pleurodesis
KW - Transforming growth factor-β
KW - Tunneled pleural catheter
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U2 - 10.1097/LBR.0000000000000022
DO - 10.1097/LBR.0000000000000022
M3 - Article
C2 - 24162112
AN - SCOPUS:84887886394
SN - 1944-6586
VL - 20
SP - 304
EP - 308
JO - Journal of Bronchology and Interventional Pulmonology
JF - Journal of Bronchology and Interventional Pulmonology
IS - 4
ER -