Transforming growth factor-β-like activity in tumors of the central nervous system

W. C. Clark, J. Bressler

Research output: Contribution to journalArticle

Abstract

Transforming growth factor type β (TGF-β) is a ubiquitous peptide with wide-ranging regulatory functions. This paper reports the initial isolation of TGF-β activity from human glial and mesenchymally derived tumors and a human glial tumor cell line. While its physiological function at the molecular level is not yet defined, it is believed that this peptide plays a central role in the control of growth and transformation, with the exact role it plays being a function of the entire set of growth factors present in a given cell.

Original languageEnglish (US)
Pages (from-to)920-924
Number of pages5
JournalJournal of neurosurgery
Volume68
Issue number6
DOIs
StatePublished - Jan 1 1988
Externally publishedYes

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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