Transforming growth factor-β

J. Massague, S. Cheifetz, Marikki Laiho, D. A. Ralph, F. M B Weis, A. Zentella

Research output: Contribution to journalArticle

Abstract

This chapter has described some of the most salient features of the biology of the TGF-βs. The TGF-βs are of great interest as growth inhibitors, regulators of cell phenotype and regulators of cell adhesion. The various TGF-β isoforms are highly conserved and display a complex pattern of interactions with multiple membrane receptor components. Activation of these receptors leads to inhibition of epithelial cell proliferation by a mechanism that may involve proteins related to the growth suppressor, RB. TGF-β receptors are also coupled to mechanisms that control expression of differentiation commitment genes and differentiated cell functions. TGF-β can affect cell proliferation and differentiation through indirect mechanisms involving regulation of expression of cytokines, extracellular matrix molecules and their respective receptors. These responses strongly influence the growth and phenotype of an array of cell types. Excess or reduced TGF-β activity may contribute to the pathogenesis of certain fibrotic disorders and certain hyperproliferative disorders including cancer, respectively.

Original languageEnglish (US)
Pages (from-to)81-103
Number of pages23
JournalCancer Surveys
Volume12
StatePublished - 1992
Externally publishedYes

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Transforming Growth Factors
Cell Proliferation
Phenotype
Growth Inhibitors
Growth
Cell Adhesion
Extracellular Matrix
Cell Differentiation
Protein Isoforms
Epithelial Cells
Cytokines
Membranes
Genes
Neoplasms
Proteins

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Massague, J., Cheifetz, S., Laiho, M., Ralph, D. A., Weis, F. M. B., & Zentella, A. (1992). Transforming growth factor-β. Cancer Surveys, 12, 81-103.

Transforming growth factor-β. / Massague, J.; Cheifetz, S.; Laiho, Marikki; Ralph, D. A.; Weis, F. M B; Zentella, A.

In: Cancer Surveys, Vol. 12, 1992, p. 81-103.

Research output: Contribution to journalArticle

Massague, J, Cheifetz, S, Laiho, M, Ralph, DA, Weis, FMB & Zentella, A 1992, 'Transforming growth factor-β', Cancer Surveys, vol. 12, pp. 81-103.
Massague J, Cheifetz S, Laiho M, Ralph DA, Weis FMB, Zentella A. Transforming growth factor-β. Cancer Surveys. 1992;12:81-103.
Massague, J. ; Cheifetz, S. ; Laiho, Marikki ; Ralph, D. A. ; Weis, F. M B ; Zentella, A. / Transforming growth factor-β. In: Cancer Surveys. 1992 ; Vol. 12. pp. 81-103.
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