Transformation with katG restores isoniazid‐sensitivity in Mycobacterium tuberculosis isolates resistant to a range of drug concentrations

Ying Zhang, Thomas Garbe, Douglas Young

Research output: Contribution to journalArticlepeer-review

Abstract

Isoniazid‐resistant isolates of Mycobacterium tuberculosis were transformed with a plasmid vector carrying the functional catalase‐peroxidase (katG) gene. Expression of katG restored full drug susceptibility in isolates initially resistant to concentrations ranging from 3.2 to >50μgml−1. Transformation with the corresponding katG gene from Escherichia coli resulted in low‐level expression of catalase and peroxidase activities and conferred partial isoniazid sensitivity.

Original languageEnglish (US)
Pages (from-to)521-524
Number of pages4
JournalMolecular Microbiology
Volume8
Issue number3
DOIs
StatePublished - May 1993

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology

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