Abstract
Isoniazid‐resistant isolates of Mycobacterium tuberculosis were transformed with a plasmid vector carrying the functional catalase‐peroxidase (katG) gene. Expression of katG restored full drug susceptibility in isolates initially resistant to concentrations ranging from 3.2 to >50μgml−1. Transformation with the corresponding katG gene from Escherichia coli resulted in low‐level expression of catalase and peroxidase activities and conferred partial isoniazid sensitivity.
Original language | English (US) |
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Pages (from-to) | 521-524 |
Number of pages | 4 |
Journal | Molecular Microbiology |
Volume | 8 |
Issue number | 3 |
DOIs | |
State | Published - May 1993 |
Externally published | Yes |
ASJC Scopus subject areas
- Microbiology
- Molecular Biology