Transformation of NIH3T3 cells with ras oncogenes abrogates the retinoic acid induction of tissue transglutaminase

Karolina Kosa, Kim Meyers, Luigi M. De Luca

Research output: Contribution to journalArticle

Abstract

Retinoic acid greatly increases enzyme activity and mRNA expression of the tissue-type transglutaminase enzyme in NIH3T3 cells. This response is blocked in cells transformed with activated H-ras, K-ras or N-ras oncogenes, but not in pSVneo vector transfected cells. Lack of induction by RA of the tissue-type TGase in these ras-transformed fibroblasts suggests intersecting pathways between retinoid action and the ras oncogene.

Original languageEnglish (US)
Pages (from-to)1025-1033
Number of pages9
JournalBiochemical and Biophysical Research Communications
Volume196
Issue number3
DOIs
StatePublished - Nov 15 1993
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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