Transformation of hamster kidney cells by simian papovavirus SA12

J. D. Valis, J. D. Strandberg, K. V. Shah

Research output: Contribution to journalArticle

Abstract

SA12, a newly recognized SV 40-related primate papovavirus, transformed early passage hamster kidney cells. These cells, designated SAHK-1, were characterized by increased saturation density, altered morphology, loss of contact inhibition, increased growth rate, an indefinite life span, reduced serum requirements for growth, an ability to grow in soft agar, and the presence of SA12-specific T-antigen. Infectious virus was not rescued by Sendai virus-induced fusion of SAHK-1 cells with permissive cells. Inoculation of transformed hamster cells into syngeneic hosts produced adenocarcinomas, undifferentiated sarcomas, and mixed tumors containing both elements. SA12 T antibodies were demonstrated in all the tested sera from tumor bearing animals.

Original languageEnglish (US)
Pages (from-to)208-212
Number of pages5
JournalExperimental Biology and Medicine
Volume160
Issue number2
StatePublished - 1979

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Viruses
Cricetinae
Tumors
Bearings (structural)
Kidney
Viral Tumor Antigens
Agar
Animals
Fusion reactions
Cells
Antibodies
Contact Inhibition
Sendai virus
Growth
Serum
Sarcoma
Primates
Neoplasms
Adenocarcinoma

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Valis, J. D., Strandberg, J. D., & Shah, K. V. (1979). Transformation of hamster kidney cells by simian papovavirus SA12. Experimental Biology and Medicine, 160(2), 208-212.

Transformation of hamster kidney cells by simian papovavirus SA12. / Valis, J. D.; Strandberg, J. D.; Shah, K. V.

In: Experimental Biology and Medicine, Vol. 160, No. 2, 1979, p. 208-212.

Research output: Contribution to journalArticle

Valis, JD, Strandberg, JD & Shah, KV 1979, 'Transformation of hamster kidney cells by simian papovavirus SA12', Experimental Biology and Medicine, vol. 160, no. 2, pp. 208-212.
Valis, J. D. ; Strandberg, J. D. ; Shah, K. V. / Transformation of hamster kidney cells by simian papovavirus SA12. In: Experimental Biology and Medicine. 1979 ; Vol. 160, No. 2. pp. 208-212.
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