Transformation of cutaneous gamma/delta T-cell lymphoma following 15 years of indolent behavior

Gregory A. Hosler, Nanette Liégeois, Grant J. Anhalt, J. Margaret Moresi

Research output: Contribution to journalArticle

Abstract

Subcutaneous gamma/delta (γ/δ) T-cell lymphoma is a rare lymphoma, characterized by its unique immunophenotype and clinical course. It has been shown to behave more aggressively than its counterpart bearing the α/β receptor and has recently been removed from the subcutaneous panniculitis-like T-cell lymphoma category for this very reason. We present a case of a patient with a 15-year running diagnosis of panniculitis. Following these years of indolent behavior, the disease began an aggressive clinical course and she was diagnosed with γ/δ T-cell lymphoma. Molecular analysis identified a T-cell clone, which through retrospective analysis, was also shown to be present in the patient's original biopsy material. We present this case as a rare example of initial indolent behavior in a lymphoma typically considered very aggressive.

Original languageEnglish (US)
Pages (from-to)1063-1067
Number of pages5
JournalJournal of Cutaneous Pathology
Volume35
Issue number11
DOIs
StatePublished - Nov 1 2008

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ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology
  • Dermatology

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