Transfontanellar duplex brain ultrasonography resistive indices as a prognostic tool in neonatal hypoxic-ischemic encephalopathy before and after treatment with therapeutic hypothermia

G. J. Gerner, V. J. Burton, A. Poretti, T. Bosemani, E. Cristofalo, A. Tekes, D. Seyfert, C. Parkinson, M. Leppert, M. Allen, T. A G M Huisman, F. J. Northington, M. V. Johnston

Research output: Contribution to journalArticle

Abstract

Objective:Prior to therapeutic hypothermia (that is, cooling), transfontanellar duplex brain sonography resistive indices (RI) were studied as a bedside non-invasive measures of cerebral hemodynamics in neonates who suffered from hypoxic-ischemic encephalopathy (HIE). We compared pre- and post-cooling RI values and examined the relationships between RI values and specific long-term neurodevelopmental outcomes.Study Design:Transfontanellar duplex brain sonography, including RI, were obtained for 28 neonates prior to cooling and for 20 neonates following cooling. All RI values were sampled in the anterior cerebral artery at the beginning of each ultrasound study. Neurodevelopmental assessment was conducted between ages 20-32 months with the Mullen Scale of Early Learning. The relationships between pre- and post-cooling RI and cognitive and motor outcomes were studied.Result:Neonates with RI values 0.60. Lower RI values were associated with specific neurodevelopmental deficits in motor skill attainment.Conclusion:Pre- and post-cooling transfontanellar duplex brain sonography RI values may be a useful prognostic tool, in conjunction with other clinical information, for neonates diagnosed with HIE. The results of this study suggest that further study of the prognostic value of RI values for short- and long-term outcomes is warranted.

Original languageEnglish (US)
Pages (from-to)202-206
Number of pages5
JournalJournal of perinatology : official journal of the California Perinatal Association
Volume36
Issue number3
DOIs
StatePublished - Mar 1 2016

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Brain Hypoxia-Ischemia
Induced Hypothermia
Ultrasonography
Brain
Anterior Cerebral Artery
Motor Skills
Hemodynamics
Learning

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Pediatrics, Perinatology, and Child Health

Cite this

@article{892318e287ff4ef5be87ae215edec70c,
title = "Transfontanellar duplex brain ultrasonography resistive indices as a prognostic tool in neonatal hypoxic-ischemic encephalopathy before and after treatment with therapeutic hypothermia",
abstract = "Objective:Prior to therapeutic hypothermia (that is, cooling), transfontanellar duplex brain sonography resistive indices (RI) were studied as a bedside non-invasive measures of cerebral hemodynamics in neonates who suffered from hypoxic-ischemic encephalopathy (HIE). We compared pre- and post-cooling RI values and examined the relationships between RI values and specific long-term neurodevelopmental outcomes.Study Design:Transfontanellar duplex brain sonography, including RI, were obtained for 28 neonates prior to cooling and for 20 neonates following cooling. All RI values were sampled in the anterior cerebral artery at the beginning of each ultrasound study. Neurodevelopmental assessment was conducted between ages 20-32 months with the Mullen Scale of Early Learning. The relationships between pre- and post-cooling RI and cognitive and motor outcomes were studied.Result:Neonates with RI values 0.60. Lower RI values were associated with specific neurodevelopmental deficits in motor skill attainment.Conclusion:Pre- and post-cooling transfontanellar duplex brain sonography RI values may be a useful prognostic tool, in conjunction with other clinical information, for neonates diagnosed with HIE. The results of this study suggest that further study of the prognostic value of RI values for short- and long-term outcomes is warranted.",
author = "Gerner, {G. J.} and Burton, {V. J.} and A. Poretti and T. Bosemani and E. Cristofalo and A. Tekes and D. Seyfert and C. Parkinson and M. Leppert and M. Allen and Huisman, {T. A G M} and Northington, {F. J.} and Johnston, {M. V.}",
year = "2016",
month = "3",
doi = "10.1038/jp.2015.169",
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pages = "202--206",
journal = "Journal of Perinatology",
issn = "0743-8346",
publisher = "Nature Publishing Group",
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T1 - Transfontanellar duplex brain ultrasonography resistive indices as a prognostic tool in neonatal hypoxic-ischemic encephalopathy before and after treatment with therapeutic hypothermia

AU - Gerner,G. J.

AU - Burton,V. J.

AU - Poretti,A.

AU - Bosemani,T.

AU - Cristofalo,E.

AU - Tekes,A.

AU - Seyfert,D.

AU - Parkinson,C.

AU - Leppert,M.

AU - Allen,M.

AU - Huisman,T. A G M

AU - Northington,F. J.

AU - Johnston,M. V.

PY - 2016/3/1

Y1 - 2016/3/1

N2 - Objective:Prior to therapeutic hypothermia (that is, cooling), transfontanellar duplex brain sonography resistive indices (RI) were studied as a bedside non-invasive measures of cerebral hemodynamics in neonates who suffered from hypoxic-ischemic encephalopathy (HIE). We compared pre- and post-cooling RI values and examined the relationships between RI values and specific long-term neurodevelopmental outcomes.Study Design:Transfontanellar duplex brain sonography, including RI, were obtained for 28 neonates prior to cooling and for 20 neonates following cooling. All RI values were sampled in the anterior cerebral artery at the beginning of each ultrasound study. Neurodevelopmental assessment was conducted between ages 20-32 months with the Mullen Scale of Early Learning. The relationships between pre- and post-cooling RI and cognitive and motor outcomes were studied.Result:Neonates with RI values 0.60. Lower RI values were associated with specific neurodevelopmental deficits in motor skill attainment.Conclusion:Pre- and post-cooling transfontanellar duplex brain sonography RI values may be a useful prognostic tool, in conjunction with other clinical information, for neonates diagnosed with HIE. The results of this study suggest that further study of the prognostic value of RI values for short- and long-term outcomes is warranted.

AB - Objective:Prior to therapeutic hypothermia (that is, cooling), transfontanellar duplex brain sonography resistive indices (RI) were studied as a bedside non-invasive measures of cerebral hemodynamics in neonates who suffered from hypoxic-ischemic encephalopathy (HIE). We compared pre- and post-cooling RI values and examined the relationships between RI values and specific long-term neurodevelopmental outcomes.Study Design:Transfontanellar duplex brain sonography, including RI, were obtained for 28 neonates prior to cooling and for 20 neonates following cooling. All RI values were sampled in the anterior cerebral artery at the beginning of each ultrasound study. Neurodevelopmental assessment was conducted between ages 20-32 months with the Mullen Scale of Early Learning. The relationships between pre- and post-cooling RI and cognitive and motor outcomes were studied.Result:Neonates with RI values 0.60. Lower RI values were associated with specific neurodevelopmental deficits in motor skill attainment.Conclusion:Pre- and post-cooling transfontanellar duplex brain sonography RI values may be a useful prognostic tool, in conjunction with other clinical information, for neonates diagnosed with HIE. The results of this study suggest that further study of the prognostic value of RI values for short- and long-term outcomes is warranted.

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