Transferring methadone-stabilized pregnant patients to buprenorphine using an immediate release morphine transition

An open-label exploratory study

Hendrée E. Jones, Patricia Suess, Donald R. Jasinski, Rolley E. Johnson

Research output: Contribution to journalArticle

Abstract

A transition from methadone to buprenorphine without intervening withdrawal symptoms is critical for advancing the treatment of opioid-dependent patients. Four pregnant inpatients were transferred from methadone (65-85 mg) to five days of immediate release morphine (IRM) and then to buprenorphine (12-28 mg). Withdrawal scores decreased during the five days of IRM and subsequently increased over the first three days on buprenorphine. The transitional use of IRM appears safe for both mother and fetus. Withdrawal symptoms appeared during buprenorphine induction; however, these data suggest that the intensity of withdrawal symptoms may be lessened by the dose and frequency of buprenorphine administration.

Original languageEnglish (US)
Pages (from-to)61-70
Number of pages10
JournalAmerican Journal on Addictions
Volume15
Issue number1
DOIs
StatePublished - 2006

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Buprenorphine
Methadone
Morphine
Substance Withdrawal Syndrome
Opioid Analgesics
Inpatients
Fetus
Mothers

ASJC Scopus subject areas

  • Medicine (miscellaneous)

Cite this

Transferring methadone-stabilized pregnant patients to buprenorphine using an immediate release morphine transition : An open-label exploratory study. / Jones, Hendrée E.; Suess, Patricia; Jasinski, Donald R.; Johnson, Rolley E.

In: American Journal on Addictions, Vol. 15, No. 1, 2006, p. 61-70.

Research output: Contribution to journalArticle

Jones, Hendrée E. ; Suess, Patricia ; Jasinski, Donald R. ; Johnson, Rolley E. / Transferring methadone-stabilized pregnant patients to buprenorphine using an immediate release morphine transition : An open-label exploratory study. In: American Journal on Addictions. 2006 ; Vol. 15, No. 1. pp. 61-70.
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