Transfer of HIV-1-specific cytotoxic T lymphocytes to an AIDS patient leads to selection for mutant HIV variants and subsequent disease progression

Scott Koenig, Anthony J. Conley, Yambasu A. Brewah, Gary M. Jones, Simon Leath, Lynn J. Boots, Victoria Davey, Guiseppi Pantaleo, James F. Demarest, Charles Carter, Christine Wannebo, John R. Yannelli, Steven A. Rosenberg, H. Clifford Lane

Research output: Contribution to journalArticle

Abstract

An HIV-1-seropositive volunteer was infused with an expanded autologous cytotoxic T lymphocyte (CTL) clone directed against the HIV-1 net protein. This clone was adoptively transferred to determine whether supplementing CTL activity could reduce viral load or improve clinical course. Unexpectedly, infusion was followed by a decline in circulating CD4+T cells and a rise in viral load. Some of the HIV isolates obtained from the plasma or CD4+cells of the patient were lacking the nef epitope. These results suggest that active CTL selection of viral variants could contribute to the pathogenesis of AIDS and that clinical progression can occur despite high levels of circulating HIV-1-specific CTLs.

Original languageEnglish (US)
Pages (from-to)330-336
Number of pages7
JournalNature medicine
Volume1
Issue number4
DOIs
StatePublished - Apr 1995

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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