Transfer of CD8+ T cells into SCID mice and activation of memory virus-specific cytotoxic T cells

F. J. Kos, A. Mullbacher

Research output: Contribution to journalArticle

Abstract

The requirements for the activation of naive and memory CD8+ cytotoxic T (Tc) cells into effector virus specific Tc cells after transferring them into SCID mice were investigated. SCID mice reconstituted with splenocytes or purified CD8+ T cells from naive or influenza-immune syngeneic mice and immunized with influenza virus generated effector Tc cells specific for influenza virus-infected target cells in vitro. The kinetics of the response varied between those two populations. The generation of effector Tc cells after transfer of memory CD8+ T cells indicates that there exists no absolute requirement for 'help' in the activation of memory virus-immune Tc cells. However, under the conditions described here the in vitro immunogenic peptide NPP derived from influenza nucleoprotein is not sufficient to elicit a response in vivo.

Original languageEnglish (US)
Pages (from-to)523-528
Number of pages6
JournalScandinavian Journal of Immunology
Volume37
Issue number4
StatePublished - 1993
Externally publishedYes

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Virus Activation
SCID Mice
T-Lymphocytes
Orthomyxoviridae
Human Influenza
Nucleoproteins
Transfer (Psychology)
Viruses
Peptides
Population

ASJC Scopus subject areas

  • Immunology

Cite this

Transfer of CD8+ T cells into SCID mice and activation of memory virus-specific cytotoxic T cells. / Kos, F. J.; Mullbacher, A.

In: Scandinavian Journal of Immunology, Vol. 37, No. 4, 1993, p. 523-528.

Research output: Contribution to journalArticle

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