Transcytolemmal water exchange in pharmacokinetic analysis of dynamic contrast-enhanced MRI data in squamous cell carcinoma of the head and neck

Sungheon Kim, Harry Quon, Laurie A. Loevner, Mark A. Rosen, Lawrence Dougherty, Alex M. Kilger, Jerry D. Glickson, Harish Poptani

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: To investigate the effect of transcytolemmal water exchange on the dynamic contrast-enhanced (DCE) T1-weighted MRI of human squamous cell carcinomas of the head and neck (HNSCC). Materials and Methods: Nine patients with HNSCC nodal metastasis underwent pretreatment DCE-MRI with a temporal resolution of 2.5 seconds and a spatial resolution of 1 mm x 1 mm x 5 mm at 1.5T. We used two pharmacokinetic models for data analysis: generalized kinetic model (GKM) without considering transcytolemmal water exchange and the shutter-speed model (SSM), based on a two-site exchange model for transcytolemmal water exchange. The results were compared in three subgroups of voxels in the tumor depending on the level of contrast enhancement. Results: SSM was found to be a better fit for more than 75% of pixels of all subjects (P < 0.01) in terms of residual size and Bayesian information criterion (BIC). For all three subgroups based on the contrast enhancement, the median K trans values of SSM were 42% to 55% higher than those of GKM and the median νe values of SSM were 116% to 176% larger than those of GKM. The median Ktrans and νe of two models were found significantly different (P < 0.01). The median τi measured by SSM were from 211 to 364 msec. Conclusion: The effect of transcytolemmal water exchange is an important factor that needs to be incorporated for adequate modeling of contrast enhancement dynamics measured by MRI of HNSCC.

Original languageEnglish (US)
Pages (from-to)1607-1617
Number of pages11
JournalJournal of Magnetic Resonance Imaging
Volume26
Issue number6
DOIs
StatePublished - Dec 2007
Externally publishedYes

Keywords

  • DCE-MRI
  • Head and neck
  • Pharmacokinetic analysis
  • Squamous cell carcinoma
  • Transcytolemmal water exchange

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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