Transcutaneous immunization: A human vaccine delivery strategy using a patch

Gregory M. Glenn, David N. Taylor, Xiuru Li, Sarah Frankel, Andrew Montemarano, Carl R. Alving

Research output: Contribution to journalArticle

Abstract

Transcutaneous immunization, a topical vaccine application, combines the advantages of needle-free delivery while targeting the immunologically rich milieu of the skin. In animal studies, this simple technique induces robust systemic and mucosal antibodies against vaccine antigens. Here, we demonstrate safe application of a patch containing heat-labile enterotoxin (LT, derived from Escherichia coli) to humans, resulting in robust LT-antibody responses. These findings indicate that TCI is feasible for human immunization, and suggest that TCI may enhance efficacy as well as improve vaccine delivery.

Original languageEnglish (US)
Pages (from-to)1403-1406
Number of pages4
JournalNature Medicine
Volume6
Issue number12
DOIs
StatePublished - 2000
Externally publishedYes

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Immunization
Vaccines
Antibodies
Enterotoxins
Needles
Escherichia coli
Antibody Formation
Skin
Animals
Hot Temperature
Antigens

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Glenn, G. M., Taylor, D. N., Li, X., Frankel, S., Montemarano, A., & Alving, C. R. (2000). Transcutaneous immunization: A human vaccine delivery strategy using a patch. Nature Medicine, 6(12), 1403-1406. https://doi.org/10.1038/82225

Transcutaneous immunization : A human vaccine delivery strategy using a patch. / Glenn, Gregory M.; Taylor, David N.; Li, Xiuru; Frankel, Sarah; Montemarano, Andrew; Alving, Carl R.

In: Nature Medicine, Vol. 6, No. 12, 2000, p. 1403-1406.

Research output: Contribution to journalArticle

Glenn, GM, Taylor, DN, Li, X, Frankel, S, Montemarano, A & Alving, CR 2000, 'Transcutaneous immunization: A human vaccine delivery strategy using a patch', Nature Medicine, vol. 6, no. 12, pp. 1403-1406. https://doi.org/10.1038/82225
Glenn GM, Taylor DN, Li X, Frankel S, Montemarano A, Alving CR. Transcutaneous immunization: A human vaccine delivery strategy using a patch. Nature Medicine. 2000;6(12):1403-1406. https://doi.org/10.1038/82225
Glenn, Gregory M. ; Taylor, David N. ; Li, Xiuru ; Frankel, Sarah ; Montemarano, Andrew ; Alving, Carl R. / Transcutaneous immunization : A human vaccine delivery strategy using a patch. In: Nature Medicine. 2000 ; Vol. 6, No. 12. pp. 1403-1406.
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