Transcriptional repression by nuclear receptors: Mechanisms and role in disease

J. D. Love, J. T. Gooch, L. Nagy, V. K.K. Chatterjee, J. W.R. Schwabe

Research output: Contribution to journalArticlepeer-review

Abstract

Co-repressor proteins mediate transcriptional repression by nuclear receptors in the absence of ligand. The identification of a co-repressor-receptor interaction motif, and the finding that co-repressors and co-activators compete for the same site on the receptor, suggests a simple mechanism for the switch from repression to activation upon ligand binding. Defects in this mechanism result in dominant-negative receptors that repress transcription. Such receptors have been implicated in several clinically important diseases, including thyroid hormone resistance and diabetes mellitus.

Original languageEnglish (US)
Pages (from-to)390-396
Number of pages7
JournalBiochemical Society transactions
Volume28
Issue number4
DOIs
StatePublished - 2000

Keywords

  • Co-activators
  • Co-repressors
  • Dominant-negative inibition
  • Nudear hormone receptors

ASJC Scopus subject areas

  • Biochemistry

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