Abstract
Co-repressor proteins mediate transcriptional repression by nuclear receptors in the absence of ligand. The identification of a co-repressor-receptor interaction motif, and the finding that co-repressors and co-activators compete for the same site on the receptor, suggests a simple mechanism for the switch from repression to activation upon ligand binding. Defects in this mechanism result in dominant-negative receptors that repress transcription. Such receptors have been implicated in several clinically important diseases, including thyroid hormone resistance and diabetes mellitus.
Original language | English (US) |
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Pages (from-to) | 390-396 |
Number of pages | 7 |
Journal | Biochemical Society transactions |
Volume | 28 |
Issue number | 4 |
DOIs | |
State | Published - 2000 |
Externally published | Yes |
Keywords
- Co-activators
- Co-repressors
- Dominant-negative inibition
- Nudear hormone receptors
ASJC Scopus subject areas
- Biochemistry