Transcriptional repression by nuclear receptors

Mechanisms and role in disease

J. D. Love, J. T. Gooch, Laszlo Nagy, V. K.K. Chatterjee, J. W.R. Schwabe

Research output: Contribution to journalArticle

Abstract

Co-repressor proteins mediate transcriptional repression by nuclear receptors in the absence of ligand. The identification of a co-repressor-receptor interaction motif, and the finding that co-repressors and co-activators compete for the same site on the receptor, suggests a simple mechanism for the switch from repression to activation upon ligand binding. Defects in this mechanism result in dominant-negative receptors that repress transcription. Such receptors have been implicated in several clinically important diseases, including thyroid hormone resistance and diabetes mellitus.

Original languageEnglish (US)
Pages (from-to)390-396
Number of pages7
JournalBiochemical Society Transactions
Volume28
Issue number4
DOIs
StatePublished - Jan 1 2000
Externally publishedYes

Fingerprint

Co-Repressor Proteins
Cytoplasmic and Nuclear Receptors
Thyroid Hormone Resistance Syndrome
Ligands
Transcription
Medical problems
Thyroid Hormones
Diabetes Mellitus
Chemical activation
Switches
Defects

Keywords

  • Co-activators
  • Co-repressors
  • Dominant-negative inibition
  • Nudear hormone receptors

ASJC Scopus subject areas

  • Biochemistry

Cite this

Transcriptional repression by nuclear receptors : Mechanisms and role in disease. / Love, J. D.; Gooch, J. T.; Nagy, Laszlo; Chatterjee, V. K.K.; Schwabe, J. W.R.

In: Biochemical Society Transactions, Vol. 28, No. 4, 01.01.2000, p. 390-396.

Research output: Contribution to journalArticle

Love, J. D. ; Gooch, J. T. ; Nagy, Laszlo ; Chatterjee, V. K.K. ; Schwabe, J. W.R. / Transcriptional repression by nuclear receptors : Mechanisms and role in disease. In: Biochemical Society Transactions. 2000 ; Vol. 28, No. 4. pp. 390-396.
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