TY - JOUR
T1 - Transcriptional repression, apoptosis, human disease and the functional evolution of the nuclear lamina
AU - Cohen, Merav
AU - Gruenbaum, Yosef
AU - Lee, Kenneth K.
AU - Wilson, Katherine L.
N1 - Funding Information:
We thank biomedical illustrator M. Linkinhoker for rendering Fig. 1 and Fig. 5 ; H. Cedar, C. Machamer, A. Simon, D. Shumaker and J. Liu for useful discussions and comments on the manuscript; and A. Simon for sharing results before publication. This work was supported by grants from the USA–Israel Binational Science Foundation (BSF), the Israel Science Foundation (ISF) #125/98 and the German–Israel Foundation (GIF) #1-573-036.13 (to Y.G.), and by grants from the W.W. Smith Charitable Trust and NIH-RO1GM48646 (to K.L.W.).
PY - 2001/1/1
Y1 - 2001/1/1
N2 - The number and complexity of genes encoding nuclear lamina proteins has increased during metazoan evolution. Emerging evidence reveals that transcriptional repressors such as the retinoblastoma protein, and apoptotic regulators such as CED-4, have functional and dynamic interactions with the lamina. The discovery that mutations in nuclear lamina proteins cause heritable tissue-specific diseases, including Emery-Dreifuss muscular dystrophy, is prompting a fresh look at the nuclear lamina to devise models that can account for its diverse functions and dynamics, and to understand its enigmatic structure.
AB - The number and complexity of genes encoding nuclear lamina proteins has increased during metazoan evolution. Emerging evidence reveals that transcriptional repressors such as the retinoblastoma protein, and apoptotic regulators such as CED-4, have functional and dynamic interactions with the lamina. The discovery that mutations in nuclear lamina proteins cause heritable tissue-specific diseases, including Emery-Dreifuss muscular dystrophy, is prompting a fresh look at the nuclear lamina to devise models that can account for its diverse functions and dynamics, and to understand its enigmatic structure.
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U2 - 10.1016/S0968-0004(00)01727-8
DO - 10.1016/S0968-0004(00)01727-8
M3 - Review article
C2 - 11165516
AN - SCOPUS:0035146907
SN - 0968-0004
VL - 26
SP - 41
EP - 47
JO - Trends in biochemical sciences
JF - Trends in biochemical sciences
IS - 1
ER -