Transcriptional regulatory network during development in the olfactory epithelium

Seung Yeong Im, Cheil Moon

Research output: Contribution to journalArticlepeer-review

Abstract

Regeneration, a process of reconstitution of the entire tissue, occurs throughout life in the olfactory epithelium (OE). Regeneration of OE consists of several stages: proliferation of progenitors, cell fate determination between neuronal and non-neuronal lineages, their differentiation and maturation. How the differentiated cell types that comprise the OE are regenerated, is one of the central questions in olfactory developmental neurobiology. The past decade has witnessed considerable progress regarding the regulation of transcription factors (TFs) involved in the remarkable regenerative potential of OE. Here, we review current state of knowledge of the transcriptional regulatory networks that are powerful modulators of the acquisition and maintenance of developmental stages during regeneration in the OE. Advance in our understanding of regeneration will not only shed light on the basic principles of adult plasticity of cell identity, but may also lead to new approaches for using stem cells and reprogramming after injury or degenerative neurological diseases.

Original languageEnglish (US)
Pages (from-to)599-608
Number of pages10
JournalBMB Reports
Volume48
Issue number11
DOIs
StatePublished - 2015
Externally publishedYes

Keywords

  • Neurogenesis
  • Olfactory epithelium
  • Regeneration
  • Stem cell
  • Transcription factor

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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