Transcriptional regulation of myelopoiesis.

Research output: Contribution to journalArticle

Abstract

A common myeloid progenitor gives rise to both granulocytes and monocytes. The early stages of granulopoiesis are mediated by the C/EBPalpha, PU.1, RAR, CBF, and c-Myb transcription factors, and the later stages require C/EBPepsilon, PU.1, and CDP. Monocyte development requires PU.1 and interferon consensus sequence binding protein and can be induced by Maf-B, c-Jun, or Egr-1. Cytokine receptor signals modulate transcription factor activities but do not determine cell fates. Several mechanisms orchestrate the myeloid developmental program, including cooperative gene regulation, protein:protein interactions, regulation of factor levels, and induction of cell cycle arrest.

Original languageEnglish (US)
Pages (from-to)466-472
Number of pages7
JournalInternational Journal of Hematology
Volume75
Issue number5
StatePublished - Jun 2002

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Myelopoiesis
Monocytes
Transcription Factors
CCAAT-Enhancer-Binding Protein-alpha
Cytidine Diphosphate
Myeloid Progenitor Cells
Cytokine Receptors
Cell Cycle Checkpoints
Granulocytes
Proteins
interferon regulatory factor-8

ASJC Scopus subject areas

  • Hematology

Cite this

Transcriptional regulation of myelopoiesis. / Friedman, Alan David.

In: International Journal of Hematology, Vol. 75, No. 5, 06.2002, p. 466-472.

Research output: Contribution to journalArticle

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