TY - JOUR
T1 - Transcriptional regulation of myelopoiesis.
AU - Friedman, Alan D.
N1 - Funding Information:
A.D.F. is a Scholar of the Leukemia and Lymphoma Society, and his research is supported by the Children’s Cancer Foundation and the NIH.
PY - 2002/6
Y1 - 2002/6
N2 - A common myeloid progenitor gives rise to both granulocytes and monocytes. The early stages of granulopoiesis are mediated by the C/EBPalpha, PU.1, RAR, CBF, and c-Myb transcription factors, and the later stages require C/EBPepsilon, PU.1, and CDP. Monocyte development requires PU.1 and interferon consensus sequence binding protein and can be induced by Maf-B, c-Jun, or Egr-1. Cytokine receptor signals modulate transcription factor activities but do not determine cell fates. Several mechanisms orchestrate the myeloid developmental program, including cooperative gene regulation, protein:protein interactions, regulation of factor levels, and induction of cell cycle arrest.
AB - A common myeloid progenitor gives rise to both granulocytes and monocytes. The early stages of granulopoiesis are mediated by the C/EBPalpha, PU.1, RAR, CBF, and c-Myb transcription factors, and the later stages require C/EBPepsilon, PU.1, and CDP. Monocyte development requires PU.1 and interferon consensus sequence binding protein and can be induced by Maf-B, c-Jun, or Egr-1. Cytokine receptor signals modulate transcription factor activities but do not determine cell fates. Several mechanisms orchestrate the myeloid developmental program, including cooperative gene regulation, protein:protein interactions, regulation of factor levels, and induction of cell cycle arrest.
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U2 - 10.1007/BF02982108
DO - 10.1007/BF02982108
M3 - Review article
C2 - 12095145
AN - SCOPUS:0242368883
SN - 0925-5710
VL - 75
SP - 466
EP - 472
JO - International journal of hematology
JF - International journal of hematology
IS - 5
ER -