Transcriptional control mechanisms in the regulation of cholesterol balance

Research output: Contribution to journalReview article

Abstract

The mechanisms that govern regulation of cholesterol metabolism in higher eukaryotic cells provide an example of how metabolic regulation has evolved to establish growth and nutritional control in a multicellular environment. Two sources of cholesterol must be balanced to ensure optimum growth and viability. Much of the control is established by regulating the levels of key proteins involved in cholesterol uptake and biosynthesis and this occurs by alterations in promoter activity. The studies discussed here track the progression in understanding the mechanism for transcriptional regulation by cholesterol from the isolation of the key genes involved, to the careful dissection of the cis-acting sequences that control expression, and on to what is currently known about the trans-acting proteins that mediate the regulatory response.

Original languageEnglish (US)
Pages (from-to)317-335
Number of pages19
JournalCritical Reviews in Eukaryotic Gene Expression
Volume5
Issue number3-4
DOIs
StatePublished - Jan 1 1995
Externally publishedYes

Keywords

  • HMG CoA synthase and reductase
  • LDL receptor
  • SREBP-1 and -2
  • sterol regulatory element

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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