Transcription through chromatin by RNA polymerase II: Histone displacement and exchange

Olga I. Kulaeva, Daria A. Gaykalova, Vasily M. Studitsky

Research output: Contribution to journalArticlepeer-review

Abstract

The process of transcript elongation by RNA polymerase II (Pol II) involves transcription-dependent exchange and displacement of all core histones and is tightly controlled by numerous protein complexes modifying chromatin structure. These processes can contribute to regulation of transcription initiation and elongation, as well as the chromatin state. Recent data suggest that the histone octamer is displaced from DNA at a high rate of transcription, but can survive less frequent transcription that is accompanied only by partial loss of H2A/H2B histones. Here we propose that critical density of Pol II molecules could be required for displacement of the histone octamer and discuss mechanisms that are most likely involved in the processes of histone exchange.

Original languageEnglish (US)
Pages (from-to)116-129
Number of pages14
JournalMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Volume618
Issue number1-2
DOIs
StatePublished - May 1 2007

Keywords

  • Chromatin
  • Elongation
  • Exchange
  • Histones
  • Nucleosome
  • Transcription

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Health, Toxicology and Mutagenesis

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