Transcription, splicing, and release: Are we there yet?

Ranjan Sen, Sebastian D. Fugmann

Research output: Contribution to journalArticle

Abstract

A systematic analysis of LPS-induced gene expression in macrophages by Bhatt et al. demonstrates that inflammatory responses are governed primarily at the level of transcription initiation. Unexpectedly, full-length nascent RNAs that contain introns appear to accumulate on chromatin, presumably to complete processing, prior to release of functional mRNA for export to the cytoplasm.

Original languageEnglish (US)
Pages (from-to)241-243
Number of pages3
JournalCell
Volume150
Issue number2
DOIs
StatePublished - Jul 20 2012
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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