Transcription program of human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus)

M. Paulose-Murphy, N. K. Ha, C. Xiang, Y. Chen, L. Gillim, R. Yarchoan, P. Meltzer, M. Bittner, J. Trent, S. Zeichner

Research output: Contribution to journalArticle

Abstract

Human herpesvirus 8 (HHV-8), a gammaherpesvirus implicated in Kaposi's sarcoma, primary effusion lymphoma, and Castleman's disease, encodes several pathogenically important cellular homologs. To define the HHV-8 transcription program, RNA obtained from latently infected body cavity-based lymphoma 1 cells induced to undergo lytic replication was used to query a custom HHV-8 DNA microarray containing nearly every known viral open reading frame. The patterns of viral gene expression offer insights into the replication and pathogenic strategies of HHV.8.

Original languageEnglish (US)
Pages (from-to)4843-4853
Number of pages11
JournalJournal of virology
Volume75
Issue number10
DOIs
StatePublished - May 9 2001

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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    Paulose-Murphy, M., Ha, N. K., Xiang, C., Chen, Y., Gillim, L., Yarchoan, R., Meltzer, P., Bittner, M., Trent, J., & Zeichner, S. (2001). Transcription program of human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus). Journal of virology, 75(10), 4843-4853. https://doi.org/10.1128/JVI.75.10.4843-4853.2001